Acute hemorrhagic edema of young children is a rare leukocytoclastic vasculitis that has been reported exclusively in small retrospective cases series, case reports, or quizzes. Considering that retrospective experience deserves confirmation in at least one observational prospective study, we present our experience with 16 children (12 boys and 4 girls, 5-28 months of age) affected by acute hemorrhagic edema. The patients were in good general conditions and with a low-grade or even absent fever. They presented with non-itching red to purpuric targetoid lesions not changing location within hours, with non-pitting and sometimes tender indurative swelling, and without mucous membrane involvement or scratch marks. Signs for articular, abdominal, or kidney involvement were absent. Antinuclear or antineutrophil cytoplasmic autoantibodies were never detected. The cases were managed symptomatically as outpatients and fully resolved within 4 weeks or less. No recurrence or familiarity was noted. Conclusion: This is the first prospective evaluation of hemorrhagic edema. Our findings emphasize its distinctive tetrad: a well-appearing child; targetoid lesions that do not change location within hours; non-pitting, sometimes tender edema; complete resolution without recurrence.

Acute hemorrhagic edema of young children : a prospective case series / A. Ferrarini, C. Benetti, P. Camozzi, A. Ostini, G.D. Simonetti, G.P. Milani, M.G. Bianchetti, S.A.G. Lava. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - 175:4(2016 Apr), pp. 557-561. [10.1007/s00431-015-2671-9]

Acute hemorrhagic edema of young children : a prospective case series

G.P. Milani;
2016

Abstract

Acute hemorrhagic edema of young children is a rare leukocytoclastic vasculitis that has been reported exclusively in small retrospective cases series, case reports, or quizzes. Considering that retrospective experience deserves confirmation in at least one observational prospective study, we present our experience with 16 children (12 boys and 4 girls, 5-28 months of age) affected by acute hemorrhagic edema. The patients were in good general conditions and with a low-grade or even absent fever. They presented with non-itching red to purpuric targetoid lesions not changing location within hours, with non-pitting and sometimes tender indurative swelling, and without mucous membrane involvement or scratch marks. Signs for articular, abdominal, or kidney involvement were absent. Antinuclear or antineutrophil cytoplasmic autoantibodies were never detected. The cases were managed symptomatically as outpatients and fully resolved within 4 weeks or less. No recurrence or familiarity was noted. Conclusion: This is the first prospective evaluation of hemorrhagic edema. Our findings emphasize its distinctive tetrad: a well-appearing child; targetoid lesions that do not change location within hours; non-pitting, sometimes tender edema; complete resolution without recurrence.
acute hemorrhagic edema of young children; antineutrophil cytoplasmic autoantibodies; child; finkelstein–seidlmayer disease; leukocytoclastic vasculitis; acute disease; antibodies, antineutrophil cytoplasmic; child, preschool; diagnosis, differential; edema; female; humans; infant; male; prospective studies; vasculitis, leukocytoclastic, cutaneous; pediatrics, perinatology and child health
Settore MED/38 - Pediatria Generale e Specialistica
apr-2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/489365
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