Despite the growing interest on the presence of illicit drugs in freshwater ecosystems, just recently the attention has been focused on their potential toxicity towards non-target aquatic species. However, these studies largely neglected the effects induced by exposure to complex mixtures of illicit drugs, which could be different compared to those caused by single psychoactive molecules. This study was aimed at investigating the genetic damage induced by a 14-day exposure to a realistic mixture of the most common illicit drugs found in surface waters worldwide (cocaine, benzoylecgonine, amphetamine, morphine and 3,4-methylenedioxymethamphetamine) on the zebra mussel (Dreissena polymorpha). The mixture caused a significant increase of DNA fragmentation and triggered the apoptotic process and micronuclei formation in zebra mussel hemocytes, pointing out its potential genotoxicity towards this bivalve species.
Genotoxic effects induced by the exposure to an environmental mixture of illicit drugs to the zebra mussel / M. Parolini, S. Magni, S. Castiglioni, A. Binelli. - In: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. - ISSN 0147-6513. - 132(2016), pp. 26-30.
|Titolo:||Genotoxic effects induced by the exposure to an environmental mixture of illicit drugs to the zebra mussel|
PAROLINI, MARCO (Corresponding)
MAGNI, STEFANO (Secondo)
BINELLI, ANDREA PAOLO (Ultimo)
|Parole Chiave:||contaminant mixture; genotoxicity; illicit drugs; zebra mussel; animals; DNA fragmentation; dreissena; fresh water; hemocytes; street drugs; water pollutants, chemical; DNA damage; pollution; public health, environmental and occupational health; health, toxicology and mutagenesis|
|Settore Scientifico Disciplinare:||Settore BIO/07 - Ecologia|
|Data di pubblicazione:||2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ecoenv.2016.05.022|
|Appare nelle tipologie:||01 - Articolo su periodico|