Surgery for prosthetic valve endocarditis : a retrospective study of a national registry†

Della Corte, A.; Di Mauro, M.; Actis Dato, G.; Barili, F.; Cugola, D.; Gelsomino, S.; Santè, P.; Carozza, A.; Della Ratta, E.; Galletti, L.; Devotini, R.; Casabona, R.; Santini, F.; Salsano, A.; Scrofani, R.; Antona, C.; De Vincentiis, C.; Biondi, A.; Beghi, C.; Cappabianca, G.; De Bonis, M.; Pozzoli, A.; Nicolini, F.; Benassi, F.; Pacini, D.; Di Bartolomeo, R.; De Martino, A.; Bortolotti, U.; Lorusso, R.; Vizzardi, E.; Di Giammarco, G.; Marinelli, D.; Villa, E.; Troise, G.; Paparella, D.; Margari, V.; Tritto, F.; Damiani, G.; Scrascia, G.; Zaccaria, S.; Renzulli, A.; Serraino, G.; Mariscalco, G.; Maselli, D.; Parolari, A.; Nappi, G.

doi:10.1093/ejcts/ezx045

We described clinical-epidemiological features of prosthetic valve endocarditis (PVE) and assessed the determinants of early surgical outcomes in multicentre design.

OBJECTIVES: We described clinical-epidemiological features of prosthetic valve endocarditis (PVE) and assessed the determinants of early surgical outcomes in multicentre design. METHODS: Data regarding 2823 patients undergoing surgery for endocarditis at 19 Italian Centers between 1979 and 2015 were collected in a database. Of them, 582 had PVE: in this group, the determinants of early mortality and complications were assessed, also taking into account the different chronological eras encompassed by the study. RESULTS: Overall hospital (30-day) mortality was 19.2% (112 patients). Postoperative complications of any type occurred in 256 patients (44%). Across 3 eras (1980-2000, 2001-08 and 2009-14), early mortality did not significantly change (20.4%, 17.1%, 20.5%, respectively, P = 0.60), whereas complication rate increased (18.5%, 38.2%, 52.8%, P < 0.001), consistent with increasing mean patient age (56 ± 14, 64 ± 15, 65 ± 14 years, respectively, P < 0.001) and median logistic EuroSCORE (14%, 21%, 23%, P = 0.025). Older age, female sex, preoperative serum creatinine >-2 mg/dl, chronic pulmonary disease, low ejection fraction, non-streptococcal aetiology, active endocarditis, preoperative intubation, preoperative shock and triple valve surgery were significantly associated with mortality. In multivariable analysis, age (OR = 1.02; P = 0.03), renal insufficiency (OR = 2.1; P = 0.05), triple valve surgery (OR = 6.9; P = 0.004) and shock (OR = 4.5; P < 0.001) were independently associated with mortality, while streptococcal aetiology, healed endocarditis and ejection fraction with survival. Adjusting for study era, preoperative shock (OR = 3; P < 0.001), Enterococcus (OR = 2.3; P = 0.01) and female sex (OR = 1.5; P = 0.03) independently predicted complications, whereas ejection fraction was protective. CONCLUSIONS: PVE surgery remains a high-risk one. The strongest predictors of early outcome of PVE surgery are related to patient's haemodynamic status and microbiological factors.

Surgery for prosthetic valve endocarditis : a retrospective study of a national registry† / A. Della Corte, M. Di Mauro, G. Actis Dato, F. Barili, D. Cugola, S. Gelsomino, P. Santè, A. Carozza, E. Della Ratta, L. Galletti, R. Devotini, R. Casabona, F. Santini, A. Salsano, R. Scrofani, C. Antona, C. De Vincentiis, A. Biondi, C. Beghi, G. Cappabianca, M. De Bonis, A. Pozzoli, F. Nicolini, F. Benassi, D. Pacini, R. Di Bartolomeo, A. De Martino, U. Bortolotti, R. Lorusso, E. Vizzardi, G. Di Giammarco, D. Marinelli, E. Villa, G. Troise, D. Paparella, V. Margari, F. Tritto, G. Damiani, G. Scrascia, S. Zaccaria, A. Renzulli, G. Serraino, G. Mariscalco, D. Maselli, A. Parolari, G. Nappi. - In: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. - ISSN 1010-7940. - (2017 Mar 13). [Epub ahead of print] [10.1093/ejcts/ezx045]