Darier-White disease (DD) is an autosomal-dominant inherited disease characterized by keratotic papules that are usually located in seborrheic areas. Systemic retinoids generally are first-line treatment in cases of diffuse DD. We report the case of an 84-year-old woman with a hypertrophic variant of DD with acral lesions. Oral retinoids (acitretin) were administered as a first treatment of DD, with good clinical results. After a few months, hemorrhagic vesicles developed on palmoplantar surfaces. Suspension of the therapy led to the disappearance of the cutaneous manifestations.
Acitretin-induced acral hemorrhagic lesions in Darier-White disease / E. Zavattaro, M. Celasco, G. Delrosso, S. Ferri, C. Bornacina, G. Valente, F. Veronese, N. Fusco, M. Gariglio, E. Colombo. - In: CUTIS. - ISSN 0011-4162. - 94:6(2014 Dec), pp. E1-E5.
Acitretin-induced acral hemorrhagic lesions in Darier-White disease
N. Fusco;
2014
Abstract
Darier-White disease (DD) is an autosomal-dominant inherited disease characterized by keratotic papules that are usually located in seborrheic areas. Systemic retinoids generally are first-line treatment in cases of diffuse DD. We report the case of an 84-year-old woman with a hypertrophic variant of DD with acral lesions. Oral retinoids (acitretin) were administered as a first treatment of DD, with good clinical results. After a few months, hemorrhagic vesicles developed on palmoplantar surfaces. Suspension of the therapy led to the disappearance of the cutaneous manifestations.
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[2014] [Cutis] Acitretin-induced acral hemorrhagic lesions in Darier-White disease.pdf
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