Background: Head and neck soft tissue sarcomas (STS) represent a rare disease. Patients and methods: One hundred and sixty-seven patients underwent surgery at our institution with an eradicating intent between 1990 and 2010. Local recurrence (LR), distant metastasis (DM) and disease-specific mortality (DSM) incidence were studied along with clinicopathological prognostic factors. Results: Ten-year crude cumulative incidence (CCI) of LR, DM and DSM were 19%, 11% and 26%, respectively (median follow-up 66 months). Independent prognostic factors for DSM were tumor size (P < 0.001) and grade (P = 0.032), while surgical margins obtained a border-line significance (0.070); LR was affected by the tumor size (P = 0.001), while DM only by grade (P = 0.047). The median survival after LR and DM were 14 months and 7 months, respectively. Tumors sited in the paranasal sinus and supraclavicular region had the worst survival. Conclusions: Head and neck represent a very critical anatomical site for STS. Achievement of local disease control appears to be crucial, since even LR could be a life-threatening event.
Head and neck soft tissue sarcomas : prognostic factors and outcome in a series of patients treated at a single institution / D. Mattavelli, R. Miceli, S. Radaelli, F. Mattavelli, G. Cantù, M. Barisella, P. Quattrone, S. Stacchiotti, C. Sangalli, P.G. Casali, A. Gronchi, M. Fiore. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 24:8(2013), pp. 2181-2189. [10.1093/annonc/mdt126]
Head and neck soft tissue sarcomas : prognostic factors and outcome in a series of patients treated at a single institution
P.G. Casali;
2013
Abstract
Background: Head and neck soft tissue sarcomas (STS) represent a rare disease. Patients and methods: One hundred and sixty-seven patients underwent surgery at our institution with an eradicating intent between 1990 and 2010. Local recurrence (LR), distant metastasis (DM) and disease-specific mortality (DSM) incidence were studied along with clinicopathological prognostic factors. Results: Ten-year crude cumulative incidence (CCI) of LR, DM and DSM were 19%, 11% and 26%, respectively (median follow-up 66 months). Independent prognostic factors for DSM were tumor size (P < 0.001) and grade (P = 0.032), while surgical margins obtained a border-line significance (0.070); LR was affected by the tumor size (P = 0.001), while DM only by grade (P = 0.047). The median survival after LR and DM were 14 months and 7 months, respectively. Tumors sited in the paranasal sinus and supraclavicular region had the worst survival. Conclusions: Head and neck represent a very critical anatomical site for STS. Achievement of local disease control appears to be crucial, since even LR could be a life-threatening event.File | Dimensione | Formato | |
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