Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.
The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease : case reports and a review of the literature / M.R. Infantino, F. Meacci, V. Grossi, M. Manfredi, F. Li Gobbi, P. Sarzi Puttini, F. Atzeni, M. Benucci. - In: IMMUNOLOGIC RESEARCH. - ISSN 0257-277X. - (2016 Jul 18), pp. 1-3. [Epub ahead of print] [10.1007/s12026-016-8836-4]
The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease : case reports and a review of the literature
M.R. Infantino
;P. Sarzi Puttini;F. AtzeniPenultimo
;
2016
Abstract
Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.File | Dimensione | Formato | |
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