Immunosenescence is characterized by a decreased ability of the immune system to respond to foreign antigens, as well as a decreased ability to maintain tolerance to self-antigens. This results in an increased susceptibility to infection and cancer and reduced responses to vaccination [1-5].The mechanisms underlying immunosenescence comprise a series of cellular and molecular events involving alteration of several biochemical pathways and different cellular populations, and for the most part our understanding of these molecular mechanisms is still fragmentary. In this review we will focus on the process of senescence associated with oxidative stress, in particular how protein oxidation alters the functionality of immune cells and how oxidative stress contributes to a chronic inflammatory process often referred as inflamm-aging. © 2011 Elsevier B.V.
Oxidative stress, inflamm-aging and immunosenescence / E.S. Cannizzo, C.C. Clement, R. Sahu, C. Follo, L. Santambrogio. - In: JOURNAL OF PROTEOMICS. - ISSN 1874-3919. - 74:11(2011), pp. 2313-2323.
|Titolo:||Oxidative stress, inflamm-aging and immunosenescence|
CANNIZZO, ELVIRA STEFANIA (Primo)
|Parole Chiave:||Aging; Immune system; Inflammation; Aging; Animals; Cell Aging; Humans; Immune System; Inflammation; Models, Biological; Nitrosation; Oxidative Stress; Protein Carbonylation; Protein Processing, Post-Translational; Biochemistry; Biophysics|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jprot.2011.06.005|
|Appare nelle tipologie:||01 - Articolo su periodico|