Purpose: Few studies investigated the role of diet on nasopharyngeal cancer (NPC) risk in non-endemic areas. The aim of this study was to assess the association between adherence to the traditional Mediterranean diet and NPC risk in a southern European low-risk population. Methods: We conducted a hospital-based case-control study in Italy, including 198 histologically confirmed NPC cases and 594 matched controls. Dietary habits were collected by means of a validated food-frequency questionnaire, including 83 foods, food groups, or beverages. Adherence to the traditional Mediterranean diet was assessed through a Mediterranean Diet Score (MDS), based on nine dietary components characterizing this dietary profile, i.e., high intake of vegetables, fruits and nuts, cereals, legumes, and fish; low intake of dairy products and meat; high monounsaturated to saturated fatty acid ratio; and moderate alcohol intake. We estimated odds ratios (ORs) of NPC, and the corresponding 95% confidence intervals (CIs), for increasing MDS (i.e., increasing adherence) using multiple logistic regression models, adjusted for major confounding factors. Results: As compared to MDS ≤ 4, the ORs of NPC were 0.83 (95% CI: 0.54–1.25) for MDS of 5 and 0.66 (95% CI: 0.44–0.99) for MDS ≥ 6, with a significant trend of decreasing risk (p 0.043). The corresponding population attributable fraction was 22%, indicating that 22% of NPC cases in this population would be avoided by shifting all subjects to a score ≥6. Conclusions: Our study supports a favorable role of the Mediterranean diet on NPC risk.

Adherence to the Mediterranean diet and nasopharyngeal cancer risk in Italy / F. Turati, F. Bravi, J. Polesel, C. Bosetti, E. Negri, W. Garavello, M. Taborelli, D. Serraino, M. Libra, M. Montella, A. Decarli, M. Ferraroni, C. La Vecchia. - In: CANCER CAUSES & CONTROL. - ISSN 0957-5243. - 28:2(2017 Feb), pp. 89-95. [10.1007/s10552-017-0850-x]

Adherence to the Mediterranean diet and nasopharyngeal cancer risk in Italy

F. Turati
;
F. Bravi
Secondo
;
E. Negri;A. Decarli;M. Ferraroni
Penultimo
;
C. La Vecchia
Ultimo
2017-02

Abstract

Purpose: Few studies investigated the role of diet on nasopharyngeal cancer (NPC) risk in non-endemic areas. The aim of this study was to assess the association between adherence to the traditional Mediterranean diet and NPC risk in a southern European low-risk population. Methods: We conducted a hospital-based case-control study in Italy, including 198 histologically confirmed NPC cases and 594 matched controls. Dietary habits were collected by means of a validated food-frequency questionnaire, including 83 foods, food groups, or beverages. Adherence to the traditional Mediterranean diet was assessed through a Mediterranean Diet Score (MDS), based on nine dietary components characterizing this dietary profile, i.e., high intake of vegetables, fruits and nuts, cereals, legumes, and fish; low intake of dairy products and meat; high monounsaturated to saturated fatty acid ratio; and moderate alcohol intake. We estimated odds ratios (ORs) of NPC, and the corresponding 95% confidence intervals (CIs), for increasing MDS (i.e., increasing adherence) using multiple logistic regression models, adjusted for major confounding factors. Results: As compared to MDS ≤ 4, the ORs of NPC were 0.83 (95% CI: 0.54–1.25) for MDS of 5 and 0.66 (95% CI: 0.44–0.99) for MDS ≥ 6, with a significant trend of decreasing risk (p 0.043). The corresponding population attributable fraction was 22%, indicating that 22% of NPC cases in this population would be avoided by shifting all subjects to a score ≥6. Conclusions: Our study supports a favorable role of the Mediterranean diet on NPC risk.
Case–control study; Mediterranean diet; Nasopharyngeal cancer; Prevention; Risk factor; Oncology; Cancer Research
Settore MED/01 - Statistica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/481569
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