Solid Lipid Nanoparticles (SLNs) composed of biodegradable physiological lipids have been widely proposed as efficient drug delivery systems, also for ophthalmic administration. Recently, chitosan-associated-SLNs have been developed to further improve the residence time of these colloidal systems in the precorneal area by means of mucoadhesive interaction. In the present study, a one-step preparation protocol was used aiming both at scale-up ease and at stronger coupling between chitosan and SLNs. The resulting particles were chitosan associated-SLNs (CS-SLNs). These nanoparticles were characterized, as compared to both the chitosan-free and the usual chitosan-coated ones, by applying a multi-technique approach: light, neutron and X-ray scattering, Zeta-potential, AFM, calorimetry. It was assessed that, while keeping the features of nano-size and surface-charge required for an efficient vector, these new nanoparticles display a strong and intimate interaction between chitosan and SLNs, far more settled than the usual simple coverage. Moreover, this one-step preparation method allows to obtain a strong and intimate interaction between chitosan and SLNs, firmer than the usual simple coating. This confers to the CS-SLNs an improved mucoadhesion, opening the way for a high-performing ophthalmic formulation.
Chitosan-coupled Solid Lipid Nanoparticles : tuning nanostructure and mucoadhesion / G. Sandri, S. Motta, M.C. Bonferoni, P. Brocca, S. Rossi, F. Ferrari, V. Rondelli, L. Cantù, C. Caramella, E. Del Favero. - In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - ISSN 0939-6411. - 110(2017 Jan), pp. 13-18.
|Titolo:||Chitosan-coupled Solid Lipid Nanoparticles : tuning nanostructure and mucoadhesion|
|Parole Chiave:||chitosan; mucoadhesion; solid lipid nanoparticles; structural analysis|
|Settore Scientifico Disciplinare:||Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)|
|Data di pubblicazione:||gen-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejpb.2016.10.010|
|Appare nelle tipologie:||01 - Articolo su periodico|
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