Growing evidences are indicating that mesenchimal stem cells may promote tendon repair via paracrine-acting molecules targeting inflammatory and trophic processes. To test this hypothesis we have studied the therapeutic potential of conditioned medium secreted by equine amniotic derived cells (AMCs-CM) in sixteen spontaneous different tendon and ligament injuries. Careful monitoring has proved the safety of these implants. Clinical outcomes were favorable and the significantly lower rate (12.5%) of re-injuries observed, compared to horses treated with bone marrow MSC, suggests that treatment with AMCs-CM has a proven efficacy. In conclusion, this study identifies AMCs-CM as a novel therapeutic biological cell-free product in the treatment of horse tendon and ligament diseases.

Clinical application of amniotic derived mesenchimal cells conditioned medium in tendon and ligament injuries of sport horses / S. Tassan, F. Cremonesi, E. Sanzogni, R. Perego, C. Perrini, A. Lange Consiglio. - In: IPPOLOGIA. - ISSN 1120-5776. - 25:2(2014 Jun), pp. 3-14.

Clinical application of amniotic derived mesenchimal cells conditioned medium in tendon and ligament injuries of sport horses

F. Cremonesi;SANZOGNI, EMMA;R. Perego;C. Perrini;A. Lange Consiglio
2014-06

Abstract

Growing evidences are indicating that mesenchimal stem cells may promote tendon repair via paracrine-acting molecules targeting inflammatory and trophic processes. To test this hypothesis we have studied the therapeutic potential of conditioned medium secreted by equine amniotic derived cells (AMCs-CM) in sixteen spontaneous different tendon and ligament injuries. Careful monitoring has proved the safety of these implants. Clinical outcomes were favorable and the significantly lower rate (12.5%) of re-injuries observed, compared to horses treated with bone marrow MSC, suggests that treatment with AMCs-CM has a proven efficacy. In conclusion, this study identifies AMCs-CM as a novel therapeutic biological cell-free product in the treatment of horse tendon and ligament diseases.
Settore VET/08 - Clinica Medica Veterinaria
IPPOLOGIA
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/480876
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