Growing evidences are indicating that mesenchimal stem cells may promote tendon repair via paracrine-acting molecules targeting inflammatory and trophic processes. To test this hypothesis we have studied the therapeutic potential of conditioned medium secreted by equine amniotic derived cells (AMCs-CM) in sixteen spontaneous different tendon and ligament injuries. Careful monitoring has proved the safety of these implants. Clinical outcomes were favorable and the significantly lower rate (12.5%) of re-injuries observed, compared to horses treated with bone marrow MSC, suggests that treatment with AMCs-CM has a proven efficacy. In conclusion, this study identifies AMCs-CM as a novel therapeutic biological cell-free product in the treatment of horse tendon and ligament diseases.
Clinical application of amniotic derived mesenchimal cells conditioned medium in tendon and ligament injuries of sport horses / S. Tassan, F. Cremonesi, E. Sanzogni, R. Perego, C. Perrini, A. Lange Consiglio. - In: IPPOLOGIA. - ISSN 1120-5776. - 25:2(2014 Jun), pp. 3-14.
|Titolo:||Clinical application of amniotic derived mesenchimal cells conditioned medium in tendon and ligament injuries of sport horses|
CREMONESI, FAUSTO (Secondo)
PERRINI, CLAUDIA (Penultimo)
LANGE CONSIGLIO, ANNA (Ultimo)
|Settore Scientifico Disciplinare:||Settore VET/08 - Clinica Medica Veterinaria|
|Data di pubblicazione:||giu-2014|
|Appare nelle tipologie:||01 - Articolo su periodico|