Chemokines modulate immune responses through their ability to orchestrate the migration of target cells. Chemokines directly induce cell migration through a distinct set of 7 transmembrane domain G protein-coupled receptors but are also recognized by a small subfamily of atypical chemokine receptors, characterized by their inability to support chemotactic activity. Atypical chemokine receptors are now emerging as crucial regulatory components of chemokine networks in a wide range of physiologic and pathologic contexts. Although a new nomenclature has been approved recently to reflect their functional distinction from their conventional counterparts, a systematic view of this subfamily is still missing. This review discusses their biochemical and immunologic properties to identify potential unifying themes in this emerging family.

Overview and potential unifying themes of the atypical chemokine receptor family / A. Vacchini, M. Locati, E.M. Borroni. - In: JOURNAL OF LEUKOCYTE BIOLOGY. - ISSN 0741-5400. - 99:6(2016 Jun), pp. 883-892. [10.1189/jlb.2MR1015-477R]

Overview and potential unifying themes of the atypical chemokine receptor family

A. Vacchini
Primo
;
M. Locati
Secondo
;
E.M. Borroni
Ultimo
2016

Abstract

Chemokines modulate immune responses through their ability to orchestrate the migration of target cells. Chemokines directly induce cell migration through a distinct set of 7 transmembrane domain G protein-coupled receptors but are also recognized by a small subfamily of atypical chemokine receptors, characterized by their inability to support chemotactic activity. Atypical chemokine receptors are now emerging as crucial regulatory components of chemokine networks in a wide range of physiologic and pathologic contexts. Although a new nomenclature has been approved recently to reflect their functional distinction from their conventional counterparts, a systematic view of this subfamily is still missing. This review discusses their biochemical and immunologic properties to identify potential unifying themes in this emerging family.
G protein coupled receptor; expression; signaling; trafficking; β-arrestin
Settore MED/04 - Patologia Generale
giu-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/480737
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