A lab-worker was infected with HIV-1 in a biosafety level-2 of containment, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone, unknowingly contaminating a safe experiment. Mode of transmission remains unclear. Caution is warranted when handling HIV-derived constructs.
Occupational HIV infection in a research laboratory with unknown mode of transmission : a case report / A. Soria, C. Alteri, G. Scarlatti, A. Bertoli, M. Tolazzi, E. Balestra, M.C. Bellocchi, F. Continenza, L. Carioti, M. Biasin, D. Trabattoni, A. Bandera, F. Ceccherini Silberstein, C.F. Perno, A. Gori. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 64:6(2017 Mar 15), pp. 810-813. [10.1093/cid/ciw851]
Occupational HIV infection in a research laboratory with unknown mode of transmission : a case report
C. Alteri;M. Biasin;D. Trabattoni;A. Bandera;C.F. Perno;A. Gori
2017
Abstract
A lab-worker was infected with HIV-1 in a biosafety level-2 of containment, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone, unknowingly contaminating a safe experiment. Mode of transmission remains unclear. Caution is warranted when handling HIV-derived constructs.
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