Parathyroid gland growth is a major cause of secondary hyperparathyroidism in renal failure. It is well known that high serum phosphate levels, low serum calcium levels and vitamin D deficiency are the three promoters of parathyroid hyperplasia in renal failure. Recent studies have investigated in depth the potential role of growth factors (transforming growth factor alpha) and their receptors (epidermal growth factor receptor) in the pathogenesis of parathyroid cell hyperplasia in chronic renal failure. The identification of molecular mechanisms involved in calcium, phosphate and vitamin D manipulations in an experimental renal failure model could help design more effective therapy for secondary hyperparathyroidism in uremic patients

Nuove acquisizioni nella patogenesi dell'iperparatiroidismo secondario = New insights in the pathogenesis of secondary hyperparathyroidism / M. Cozzolino, A. Butti, G. Chiarelli, L. Rocca-Rey, A. Bellasi, A. Galassi, M. Gallieni, D. Brancaccio. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 0393-5590. - 22:4(2005 Jul), pp. 329-336.

Nuove acquisizioni nella patogenesi dell'iperparatiroidismo secondario = New insights in the pathogenesis of secondary hyperparathyroidism

M. Cozzolino;A. Butti;G. Chiarelli;L. Rocca-Rey;A. Bellasi;A. Galassi;M. Gallieni;D. Brancaccio
2005-07

Abstract

Parathyroid gland growth is a major cause of secondary hyperparathyroidism in renal failure. It is well known that high serum phosphate levels, low serum calcium levels and vitamin D deficiency are the three promoters of parathyroid hyperplasia in renal failure. Recent studies have investigated in depth the potential role of growth factors (transforming growth factor alpha) and their receptors (epidermal growth factor receptor) in the pathogenesis of parathyroid cell hyperplasia in chronic renal failure. The identification of molecular mechanisms involved in calcium, phosphate and vitamin D manipulations in an experimental renal failure model could help design more effective therapy for secondary hyperparathyroidism in uremic patients
vitamin D deficiency ; hyperplasia ; hyperparathyroidism, secondary ; phosphates ; calcium ; receptor, epidermal growth factor ; transforming growth factor alpha ; humans ; kidney failure, chronic ; parathyroid glands
Settore MED/14 - Nefrologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/47677
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