Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS.
Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis / C. Ferrarese, G. Sala, R. Riva, B. Begni, C. Zoia, L. Tremolizzo, G. Galimberti, A. Millul, A. Bastone, T. Mennini, C. Balzarini, L. Frattola, E. Beghi, A. Micheli, G. Moretto, C. Caponnetto, M. Ceroni, D. Alimonti, G. Siciliano, E. Pastorini, M. Bonomi, L. Carvelli. - In: NEUROLOGY. - ISSN 0028-3878. - 56:2(2001 Jan 23), pp. 270-272.
Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis
M. BonomiPenultimo
;
2001
Abstract
Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS.File | Dimensione | Formato | |
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