Background: Pneumococcal CAP is frequently associated with chest X-ray findings suggesting alveolar involvement. Recently, it has been reported that determination of nasopharyngeal SP load could be useful for the identification of pneumococcal etiology in CAP. However, no data are available about the association between nasopharyngeal SP load and alveolar CAP as well as the relevance of viral coinfections in conditioning bacterial load. Methods: On nasopharyngeal secretions of 386 children aged <5 years with radiographically-confirmed CAP, the presence of 17 viruses and Sp was evaluated by means of Luminex xTAG Respiratory Virus Panel Fast assay and by specific Real-Time polymerase chain reaction (PCR) for LytA and Wgz (cpsA) Sp genes. Nasopharyngeal Sp load was calculated and analyzed according to chest X-ray characteristics. Conclusion: Higher nasopharyngeal Sp load is more common in children with alveolar CAP suggesting that determination of this variable can contribute to the definition of pneumococcal etiology of CAP. Viral coinfections do not influence bacterial load.

Use of nasopharyngeal Streptococcus Pneumoniae (Sp) load to define pneumococcal etiology of community acquired pneumonia (CAP) / L. Terranova, C. Daleno, R. Tenconi, L. Castellazzi, L. Senatore, A. Zampiero, N. Principi. ((Intervento presentato al convegno Annual meeting of the european society for paediatric infectious diseases tenutosi a Milano nel 2013.

Use of nasopharyngeal Streptococcus Pneumoniae (Sp) load to define pneumococcal etiology of community acquired pneumonia (CAP)

L. Terranova
Primo
;
R. Tenconi;L. Senatore;A. Zampiero
Penultimo
;
N. Principi
Ultimo
2013-06-28

Abstract

Background: Pneumococcal CAP is frequently associated with chest X-ray findings suggesting alveolar involvement. Recently, it has been reported that determination of nasopharyngeal SP load could be useful for the identification of pneumococcal etiology in CAP. However, no data are available about the association between nasopharyngeal SP load and alveolar CAP as well as the relevance of viral coinfections in conditioning bacterial load. Methods: On nasopharyngeal secretions of 386 children aged <5 years with radiographically-confirmed CAP, the presence of 17 viruses and Sp was evaluated by means of Luminex xTAG Respiratory Virus Panel Fast assay and by specific Real-Time polymerase chain reaction (PCR) for LytA and Wgz (cpsA) Sp genes. Nasopharyngeal Sp load was calculated and analyzed according to chest X-ray characteristics. Conclusion: Higher nasopharyngeal Sp load is more common in children with alveolar CAP suggesting that determination of this variable can contribute to the definition of pneumococcal etiology of CAP. Viral coinfections do not influence bacterial load.
Settore MED/38 - Pediatria Generale e Specialistica
Use of nasopharyngeal Streptococcus Pneumoniae (Sp) load to define pneumococcal etiology of community acquired pneumonia (CAP) / L. Terranova, C. Daleno, R. Tenconi, L. Castellazzi, L. Senatore, A. Zampiero, N. Principi. ((Intervento presentato al convegno Annual meeting of the european society for paediatric infectious diseases tenutosi a Milano nel 2013.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/470651
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