Unconscious patients admitted to critical care units after out-of-hospital cardiac arrest are at high risk for death, and neurologic deficits are common among those who survive. The target temperature management (TTM), 33 vs. 36 °C, after out-of-hospital cardiac arrest trial was conducted to assess the benefits and harms of two targeted temperature regimens after out-of-hospital cardiac arrest of presumed cardiac cause. The study randomized 950 unconscious survivors of out-of-hospital cardiac arrest with presumed cardiac cause to a target temperature of 33 vs. 36 °C following return of spontaneous circulation (ROSC), irrespective of the initial rhythm. At the end of the trial, 50 % of the patients in the 33 °C group (235 of 473 patients) had died, as compared to 48 % of the patients in the 36 °C group (225 of 466 patients) [hazard ratio with a temperature of 33 °C 1.06; 95 % confidence interval (CI) 0.89–1.28; p = 0.51]. In unconscious survivors of out-of-hospital cardiac arrest of presumed cardiac cause, hypothermia at a targeted temperature of 33 °C does not confer a survival benefit as compared to a targeted temperature of 36 °C.
Therapeutic induced hypothermia does not improve the prognosis of out-of-hospital cardiac arrest patients / B. Granberg, E. McGillis, M. Solbiati. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 9:6(2014), pp. 677-679.
|Titolo:||Therapeutic induced hypothermia does not improve the prognosis of out-of-hospital cardiac arrest patients|
SOLBIATI, MONICA (Corresponding)
|Parole Chiave:||Cardiac arrest; Mortality; Poor neurologic outcome; Therapeutic induced hypothermia; Humans; Out-of-Hospital Cardiac Arrest; Prognosis; Unconsciousness; Hypothermia, Induced; Emergency Medicine; Internal Medicine; Medicine (all)|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11739-014-1100-9|
|Appare nelle tipologie:||01 - Articolo su periodico|