In this paper, we analyze the epicardial electromechanical response of an in silico cardiac ventricular wedge under both healthy and concentric hypertrophic conditions. This is achieved by taking into account the growth of the wedge thickness and the fiber dispersion that may follow. The electromechanical response is described in terms of some macroscopic measures, i.e. the action potential duration, the conduction velocity, the contractility and the contraction force. Our results suggest that growth reduces the action potential duration and conduction velocity, whilst it increases the contractility and contraction force, yielding an overall negative effect. In presence of fiber dispersion, the action potential duration and conduction velocity are not affected further, whilst the effect on the contractility and contraction force is enhanced.
Simulating the effects of growth and fiber dispersion on the electromechanical response of a cardiac ventricular wedge affected from concentric hypertrophy / F. Del Bianco, P.C. Franzone, S. Scacchi, L. Fassina (PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). - In: Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the[s.l] : IEEE, 2016. - ISBN 9781457702204. - pp. 5579-5582 (( Intervento presentato al 38. convegno Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 tenutosi a Orlando nel 2016 [10.1109/EMBC.2016.7591991].
Simulating the effects of growth and fiber dispersion on the electromechanical response of a cardiac ventricular wedge affected from concentric hypertrophy
S. ScacchiPenultimo
;
2016
Abstract
In this paper, we analyze the epicardial electromechanical response of an in silico cardiac ventricular wedge under both healthy and concentric hypertrophic conditions. This is achieved by taking into account the growth of the wedge thickness and the fiber dispersion that may follow. The electromechanical response is described in terms of some macroscopic measures, i.e. the action potential duration, the conduction velocity, the contractility and the contraction force. Our results suggest that growth reduces the action potential duration and conduction velocity, whilst it increases the contractility and contraction force, yielding an overall negative effect. In presence of fiber dispersion, the action potential duration and conduction velocity are not affected further, whilst the effect on the contractility and contraction force is enhanced.File | Dimensione | Formato | |
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