The ring closing under SL-PTC conditions of hydroxysulfonamides 7, bearing a leaving group in the ortho position of the aryl moiety, generates 2-substituted-3,4-dihydro-2H-1,4-benzoxazines 4 in good to excellent yields. In the case of hydroxysulfonamides 7 bearing a bromine or iodine atom as leaving groups, a copper (I) salt is used to enable the reaction to occur
Synthesis of 2-substituted 3,4-dihydro-2H-1,4-benzoxazines through ligandless copper-catalyzed cyclization of hydroxysulfonamide under phase-transfer catalysis conditions / D. Albanese, D. Landini, V. Lupi, M. Penso, D. Scaletti. - In: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL. - ISSN 1381-1169. - 2008:288(2008), pp. 28-32.
Synthesis of 2-substituted 3,4-dihydro-2H-1,4-benzoxazines through ligandless copper-catalyzed cyclization of hydroxysulfonamide under phase-transfer catalysis conditions
D. AlbanesePrimo
;D. LandiniSecondo
;
2008
Abstract
The ring closing under SL-PTC conditions of hydroxysulfonamides 7, bearing a leaving group in the ortho position of the aryl moiety, generates 2-substituted-3,4-dihydro-2H-1,4-benzoxazines 4 in good to excellent yields. In the case of hydroxysulfonamides 7 bearing a bromine or iodine atom as leaving groups, a copper (I) salt is used to enable the reaction to occur
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