T cell receptor, accessory molecules, cytokines are important regulatory factors that determine the development and function of T lymphocytes. Among them are also molecules belonging to superfamily of tumor necrosis factor receptor (TNFR) which beside CD30 include CD27, CD40, TNFR-I and -II, Fas (CD95), OX40, 4-1BB (CDw137), nerve growth factor receptor, lymphotoxin-beta receptor, Apo3/DR3/Ws1-1/lymphocyte associated receptor of death, DR4, DR5/TNF-related apoptosis-inducing ligand, osteoprotegerin, and TNFR-related 2. CD30 recognized originally on Reed-Sternberg cells of Hodgkin's lymphoma became of interest in studies of Th1 and Th2 cell differentiation. This paper shows recent findings regarding CD30 expression and its pleiotropic role in T cell function. It provides information about controversial role of CD30 as Th2 cell differentiation marker and gives concise insight into the function of this receptor as a signal transducing molecule.
Expression and function of CD30 on T lymphocytes / M. Tarkowski. - In: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. - ISSN 0004-069X. - 47:4(1999), pp. 217-221.
|Titolo:||Expression and function of CD30 on T lymphocytes|
TARKOWSKI, MACIEJ STANISLAW (Primo)
|Parole Chiave:||CD30; Cytokines; T cells|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||1999|
|Appare nelle tipologie:||01 - Articolo su periodico|