Background/Objectives:The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass.Subjects/Methods:We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes.Results:Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls.Conclusions:In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.

Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity / B. Rachid, S. Van De Sande Lee, S. Rodovalho, F. Folli, G.C. Beltramini, J. Morari, B.J. Amorim, T. Pedro, A.F. Ramalho, B. Bombassaro, A.J. Tincani, E. Chaim, J.C. Pareja, B. Geloneze, C.D. Ramos, F. Cendes, M.J.A. Saad, L.A. Velloso. - In: INTERNATIONAL JOURNAL OF OBESITY. - ISSN 0307-0565. - 39:10(2015), pp. 1515-1522. [10.1038/ijo.2015.94]

Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity

F. Folli;
2015

Abstract

Background/Objectives:The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass.Subjects/Methods:We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes.Results:Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls.Conclusions:In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.
Medicine (miscellaneous); Endocrinology, Diabetes and Metabolism; Nutrition and Dietetics
Settore MED/09 - Medicina Interna
2015
Article (author)
File in questo prodotto:
File Dimensione Formato  
ijo201594a.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 2.5 MB
Formato Adobe PDF
2.5 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/469108
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 39
  • ???jsp.display-item.citation.isi??? 34
social impact