Objective: The aim of our study was to assess myocytes apoptosis/mitosis and associated intracellular signalling pathways during heart development. Setting and patients: Eight human fetal hearts (at different gestation ages) and seven human adult hearts were chosen as controls (five normal and two pathological) and studied from both a histological and a molecular point of view. Results: Our results are as follows: (i) all Shc isoforms are expressed and activated in the human fetal heart; (ii) a progressive fading of Shc and ERK expression are evident during gestation; (iii) JNK is present but it is not activated in the human fetal heart; (iv) CD95 is present in the first week of gestation and fades progressively; (v) apoptotic/proliferative processes are present in the early gestation phase and fades progressively; (vi) in the human heart, Shc isoform with medium weight is 55 kD and not 52 kD and it is upregulated in adult myocardial ischaemia. Conclusions: Myocyte underwent apoptosis/mitosis during gestation. Shc isoforms, together with ERK maintain the homeostasis of the heart.

Apoptotic/mytogenic pathways during human heart development / P. Fiorina, D. Corradi, S. Pinelli, R. Maestri, C. Lagrasta, M. Buscaglia, A. Davalli, F. Folli, E. Astorri. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 96:3(2004), pp. 409-417.

Apoptotic/mytogenic pathways during human heart development

P. Fiorina;F. Folli;
2004

Abstract

Objective: The aim of our study was to assess myocytes apoptosis/mitosis and associated intracellular signalling pathways during heart development. Setting and patients: Eight human fetal hearts (at different gestation ages) and seven human adult hearts were chosen as controls (five normal and two pathological) and studied from both a histological and a molecular point of view. Results: Our results are as follows: (i) all Shc isoforms are expressed and activated in the human fetal heart; (ii) a progressive fading of Shc and ERK expression are evident during gestation; (iii) JNK is present but it is not activated in the human fetal heart; (iv) CD95 is present in the first week of gestation and fades progressively; (v) apoptotic/proliferative processes are present in the early gestation phase and fades progressively; (vi) in the human heart, Shc isoform with medium weight is 55 kD and not 52 kD and it is upregulated in adult myocardial ischaemia. Conclusions: Myocyte underwent apoptosis/mitosis during gestation. Shc isoforms, together with ERK maintain the homeostasis of the heart.
Apoptosis; Heart development; Myocardial infarction; Myocytes; Cardiology and Cardiovascular Medicine
Settore MED/09 - Medicina Interna
INTERNATIONAL JOURNAL OF CARDIOLOGY
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0167527303005400-main.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 728.22 kB
Formato Adobe PDF
728.22 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/469074
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 22
social impact