Objective: The aim of our study was to assess myocytes apoptosis/mitosis and associated intracellular signalling pathways during heart development. Setting and patients: Eight human fetal hearts (at different gestation ages) and seven human adult hearts were chosen as controls (five normal and two pathological) and studied from both a histological and a molecular point of view. Results: Our results are as follows: (i) all Shc isoforms are expressed and activated in the human fetal heart; (ii) a progressive fading of Shc and ERK expression are evident during gestation; (iii) JNK is present but it is not activated in the human fetal heart; (iv) CD95 is present in the first week of gestation and fades progressively; (v) apoptotic/proliferative processes are present in the early gestation phase and fades progressively; (vi) in the human heart, Shc isoform with medium weight is 55 kD and not 52 kD and it is upregulated in adult myocardial ischaemia. Conclusions: Myocyte underwent apoptosis/mitosis during gestation. Shc isoforms, together with ERK maintain the homeostasis of the heart.
Apoptotic/mytogenic pathways during human heart development / P. Fiorina, D. Corradi, S. Pinelli, R. Maestri, C. Lagrasta, M. Buscaglia, A. Davalli, F. Folli, E. Astorri. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 96:3(2004), pp. 409-417.
|Titolo:||Apoptotic/mytogenic pathways during human heart development|
FOLLI, FRANCO (Penultimo)
|Parole Chiave:||Apoptosis; Heart development; Myocardial infarction; Myocytes; Cardiology and Cardiovascular Medicine|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ijcard.2003.08.010|
|Appare nelle tipologie:||01 - Articolo su periodico|