We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
PET evidence of central GABAergic changes in stiff-person syndrome / D. Perani, V. Garibotto, A. Panzacchi, R.M. Moresco, P. Ortelli, M. Corbo, F. Fazio, F. Folli. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 22:7(2007), pp. 1030-1033.
PET evidence of central GABAergic changes in stiff-person syndrome
F. FolliUltimo
2007
Abstract
We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Perani_et_al-2007-Movement_Disorders.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
79.98 kB
Formato
Adobe PDF
|
79.98 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
