We describe 2 human immunodeficiency virus-infected patients who developed hypertension and severe neurological abnormalities while receiving successful antiretroviral therapy. Neuroimaging findings were characteristic of reversible posterior leukoencephalopathy syndrome, a brain-capillary leak syndrome with hypertension and endothelial damage. We discuss the role of antiretroviral therapy-associated metabolic alterations in endothelial damage, hypertension, and reversible posterior leukoencephalopathy syndrome.
Reversible posterior leukoencephalopathy syndrome in 2 HIV-infected patients receiving antiretroviral therapy / A.L. Ridolfo, F. Resta, L. Milazzo, I. Caramma, G. Matacena, S. Antinori, M. Galli. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 46:2(2008), pp. e19-e22.
Reversible posterior leukoencephalopathy syndrome in 2 HIV-infected patients receiving antiretroviral therapy
I. Caramma;S. AntinoriPenultimo
;M. GalliUltimo
2008
Abstract
We describe 2 human immunodeficiency virus-infected patients who developed hypertension and severe neurological abnormalities while receiving successful antiretroviral therapy. Neuroimaging findings were characteristic of reversible posterior leukoencephalopathy syndrome, a brain-capillary leak syndrome with hypertension and endothelial damage. We discuss the role of antiretroviral therapy-associated metabolic alterations in endothelial damage, hypertension, and reversible posterior leukoencephalopathy syndrome.Pubblicazioni consigliate
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