A new dic(7;12)(p12.21;p12.2) chromosome aberration was identified in an acute myeloid leukemia with FAB-M1 morphology and was cloned. Fluorescence in situ hybridization and genomic quantitative polymerase chain reaction mapping experiments revealed the precise localization of the breakpoints, at 7p12, just 5′ to the GRB10 gene, and 12p11, within a genomic region containing no known genes. As a result, a new dicentric chromosome is created, dic(7;12), with the consequent deletion of 50 Mb at 7p, from the telomere to the GRB10 region, and of 30 Mb at 12p, from the telomere to p11. Several genes are included in the affected areas.
A new chromosome aberration in a case of acute myeloid leukemia / C. Tapinass, E. Gerbino, O. Malazzi, C. Micucci, P. Gasparini, M.J. Najera, M.J. Calasanz, M.D. Odero, P.G. Pelicci, E. Belloni. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - 185:2(2008 Sep), pp. 102-105.
A new chromosome aberration in a case of acute myeloid leukemia
P.G. PelicciPenultimo
;
2008
Abstract
A new dic(7;12)(p12.21;p12.2) chromosome aberration was identified in an acute myeloid leukemia with FAB-M1 morphology and was cloned. Fluorescence in situ hybridization and genomic quantitative polymerase chain reaction mapping experiments revealed the precise localization of the breakpoints, at 7p12, just 5′ to the GRB10 gene, and 12p11, within a genomic region containing no known genes. As a result, a new dicentric chromosome is created, dic(7;12), with the consequent deletion of 50 Mb at 7p, from the telomere to the GRB10 region, and of 30 Mb at 12p, from the telomere to p11. Several genes are included in the affected areas.
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