DSPG had a definite but relatively feeble immunosuppressive effect in rats undergoing heterotopic heart transplantation and in dogs after renal transplantation. The drug was toxic in both species, although less so in rats. In dogs, synergistic interactions with cyclosporine and steroids were not evident.
Effect of 15-deoxyspergualin on experimental organ transplantation / S. Todo, N. Murase, D. Kahn, C.E. Pan, K. Okuda, S. Cemej, A. Casavilla, V. Mazzaferro, A. Ghalab, B.S. Rhoe, M. Yang, K. Taniguchi, M. Nalesnik, L. Makowka, T.E. Starzl. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 20:1 suppl. 1(1988), pp. 233-236.
Effect of 15-deoxyspergualin on experimental organ transplantation
V. Mazzaferro;
1988
Abstract
DSPG had a definite but relatively feeble immunosuppressive effect in rats undergoing heterotopic heart transplantation and in dogs after renal transplantation. The drug was toxic in both species, although less so in rats. In dogs, synergistic interactions with cyclosporine and steroids were not evident.
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