The lymphatic system plays an important role in the induction of the immune response by transporting antigens, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes. It is emerging that lymphatic endothelial cells (LECs) are playing an active role in this context via the expression of chemokines, inflammatory mediators promoting cell migration, and chemokine receptors. Particularly, LECs express atypical chemokine receptors (ACKRs), which are unable to promote conventional signaling and cell migration while they are involved in the regulation of chemokine availability. Here, we provide a summary of the data on the role of ACKR2 expressed by lymphatics, indicating an essential role for this ACKRs in the regulation of the inflammation and the immune response in different pathological conditions, including infection, allergy, and cancer.
ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology / O. Bonavita, V. Mollica Poeta, E. Setten, M. Massara, R. Bonecchi. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 7(2017), pp. 691.1-691.6.
|Titolo:||ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology|
BONAVITA, ORNELLA (Primo)
MASSARA, MATTEO (Penultimo)
BONECCHI, RAFFAELLA (Corresponding)
|Parole Chiave:||chemokine; chemokine receptor; atypical chemokine receptor; lymphatic vessels; inflammation|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3389/fimmu.2016.00691|
|Appare nelle tipologie:||01 - Articolo su periodico|