Aims: Human herpesvirus-6 (HHV-6) and polyomaviruses (HPyV) establish latency and reactivate in immunocompromised hosts. The prevalence of their infections was investigated in pediatric and young adult kidney transplant recipients. Materials & methods: Blood was obtained from 83 patients. Quantitative real-time polymerase chain reactions were conducted to quantify HHV-6 and HPyV loads; nested PCR and reverse transcriptase-PCR assays were conducted to differentiate HHV-6A from 6B and to evaluate the presence of transcripts. Results: HHV-6 and HPyV DNAemia were detected in 19.3 and 18.1% patients, respectively. No association between HHV-6 and HPyV DNA presence, age of patients and time from transplant was observed. Conclusion: HHV-6 infection in immunosuppression setting was as common as those of HPyVs that are commonly recognized as opportunistic agents.
Human herpesvirus-6 and polyomaviruses DNAemia in children and young adult patients after kidney transplantation / R. Bella, M. Dolci, M. Ferraresso, R. Ticozzi, L. Ghio, J. Rizzo, L. Signorini, S. Villani, F. Elia, P. Ferrante, S. Delbue. - In: FUTURE VIROLOGY. - ISSN 1746-0794. - 10:12(2015), pp. 1275-1284.
|Titolo:||Human herpesvirus-6 and polyomaviruses DNAemia in children and young adult patients after kidney transplantation|
BELLA, RAMONA (Primo)
FERRANTE, PASQUALE (Penultimo)
DELBUE, SERENA (Corresponding)
|Parole Chiave:||children; HHV-6A and 6B; immunosuppression; kidney transplantation; viral reactivation; Virology|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore MED/14 - Nefrologia
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2217/fvl.15.98|
|Appare nelle tipologie:||01 - Articolo su periodico|