The role of neutrophils in cancer and metastasis is still debated and controversial since they have been shown to be endowed with both pro- and antitumor functions. These contradictory results seem to be now explained by recent discoveries of tumor-associated neutrophils plasticity and multiple neutrophil subsets. Chemokines and chemokine receptors are known to tightly regulate the release of neutrophils from the bone marrow, their passage into circulation and transmigration into the tissues as well as tumor infiltration. It is emerging that chemokine receptors are differentially expressed by neutrophil subsets and they affect not only their recruitment but also their effector functions. Here we are resuming human and murine data suggesting that therapeutic modulation of neutrophil activity through the targeting of specific chemokines or chemokine receptors can improve their anti-tumoral properties.

Chemokine regulation of neutrophil function in tumors / O. Bonavita, M. Massara, R. Bonecchi. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - 30:Special Issue(2016 Aug 30), pp. 81-86. [10.1016/j.cytogfr.2016.03.012]

Chemokine regulation of neutrophil function in tumors

O. Bonavita
Primo
;
M. Massara
Secondo
;
2016

Abstract

The role of neutrophils in cancer and metastasis is still debated and controversial since they have been shown to be endowed with both pro- and antitumor functions. These contradictory results seem to be now explained by recent discoveries of tumor-associated neutrophils plasticity and multiple neutrophil subsets. Chemokines and chemokine receptors are known to tightly regulate the release of neutrophils from the bone marrow, their passage into circulation and transmigration into the tissues as well as tumor infiltration. It is emerging that chemokine receptors are differentially expressed by neutrophil subsets and they affect not only their recruitment but also their effector functions. Here we are resuming human and murine data suggesting that therapeutic modulation of neutrophil activity through the targeting of specific chemokines or chemokine receptors can improve their anti-tumoral properties.
cancer; chemokines; inflammation; neutrophils; immunology and allergy; endocrinology, diabetes and metabolism; immunology; biochemistry, genetics and molecular biology (all)
Settore MED/04 - Patologia Generale
30-ago-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/466803
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