The palladium catalyzed reductive cyclization of substituted ortho-nitrostyrenes is a powerful method for the synthesis of indoles. The reaction proceeds using CO as the reductant [1]. However CO is a highly toxic gas and its use implies the installation of expensive safety measures and high-pressure equipments. Therefore carbonylation reactions using non-gaseous CO precursors are highly desirable [2]. For our purpose we chose formate esters as the CO sources due their commercial availability and low cost. Thus, we developed a one-pot two-catalysts system composed of Ru3(CO)12 and [Pd(Phen)2][BF4]2 for the decarbonylation and the reductive cyclization step respectively. As the result various 2,6-substituted indoles were synthesized in good yields using a cheap and safe CO source [3].
Indole synthesis by reductive cyclization of ortho-nitrostyrenes: formate ester as CO surrogates / D. Formenti, F. Ferretti, F. Ragaini. ((Intervento presentato al 14. convegno Sigma-Aldrich Young Chemists Symposium tenutosi a Riccione nel 2014.
Titolo: | Indole synthesis by reductive cyclization of ortho-nitrostyrenes: formate ester as CO surrogates | |
Autori: | FORMENTI, DARIO (Primo) FERRETTI, FRANCESCO MARIA (Secondo) RAGAINI, FABIO ATTILIO CIRILLO (Ultimo) | |
Data di pubblicazione: | 2014 | |
Settore Scientifico Disciplinare: | Settore CHIM/03 - Chimica Generale e Inorganica | |
Enti collegati al convegno: | Sigma Aldrich | |
Tipologia: | Conference Object | |
Citazione: | Indole synthesis by reductive cyclization of ortho-nitrostyrenes: formate ester as CO surrogates / D. Formenti, F. Ferretti, F. Ragaini. ((Intervento presentato al 14. convegno Sigma-Aldrich Young Chemists Symposium tenutosi a Riccione nel 2014. | |
Appare nelle tipologie: | 14 - Intervento a convegno non pubblicato |