Preclinical models and clinical retrospective data indicate that obesity is associated with a significant increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. As discussed in the present review, both soluble factors and cellular players are involved in the mechanisms promoting local and metastatic breast cancer progression by adipose tissue. As the incidence of obesity is increasing worldwide, there is an urgent need for adequate preclinical models and preclinical and clinical studies designed to investigate how to inhibit the tumor-promoting activity of the adipose tissue.
Mechanisms of obesity in the development of breast cancer / S. Orecchioni, F. Reggiani, G. Talarico, F. Bertolini. - In: DISCOVERY MEDICINE. - ISSN 1539-6509. - 20:109(2015 Sep), pp. 121-128.
Mechanisms of obesity in the development of breast cancer
F. ReggianiPrimo
;
2015
Abstract
Preclinical models and clinical retrospective data indicate that obesity is associated with a significant increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. As discussed in the present review, both soluble factors and cellular players are involved in the mechanisms promoting local and metastatic breast cancer progression by adipose tissue. As the incidence of obesity is increasing worldwide, there is an urgent need for adequate preclinical models and preclinical and clinical studies designed to investigate how to inhibit the tumor-promoting activity of the adipose tissue.Pubblicazioni consigliate
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