We characterized three subsets of NK cells in blood, and two subsets in mucosal tissues. SIVmac251 infection increased total and CD16+ NK cells in the blood. In the rectum, we observed a significant increase in total and NKG2A+ NK cells during SIV infection. In contrast, the NKp44+ subset significantly depleted in acute infection and continued to decline in frequency during chronic phase. During SIV infection, blood CD16 and mucosal NKG2A+ subsets had increased cytotoxic potential. Intriguingly, the NKp44+ NK cell subtype that likely mediates mucosal homeostasis via the production of cytokines, acquired cytotoxicity. Antiretroviral therapy significantly increased the frequency of mucosal NKG2A+ NK cells and peripheral CD16+ NK cells. However, it failed to restore the normal frequency of NKp44+ NK cells in the rectum. Thus, SIVmac251 infection causes changes in the distribution and function of NK cells and antiretroviral therapy during chronic infection only partially restores NK homeostasis and function. © 2013.
Antiretroviral therapy partly reverses the systemic and mucosal distribution of NK cell subsets that is altered by SIVmac251 infection of macaques / N.P.M. Liyanage, S.N. Gordon, M.N. Doster, P. Pegu, M. Vaccari, N. Shukur, L. Schifanella, C.A. Pise-Masison, D. Lipinska, K. Grubczak, M. Moniuszko, G. Franchini. - In: VIROLOGY. - ISSN 0042-6822. - 450-451(2014), pp. 359-368.
|Titolo:||Antiretroviral therapy partly reverses the systemic and mucosal distribution of NK cell subsets that is altered by SIVmac251 infection of macaques|
|Parole Chiave:||ART; Chemokine receptor; HAART; HIV; Innate immunity; Innate lymphoid cells; Macaques; Mucosal; NK cell; SIV; Animals; Anti-HIV Agents; Disease Models, Animal; HIV Infections; HIV-1; Humans; Killer Cells, Natural; Leukocyte Count; Macaca; Macaca mulatta; Mucous Membrane; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Virology|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
Settore BIO/19 - Microbiologia Generale
Settore MED/04 - Patologia Generale
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.virol.2013.12.003|
|Appare nelle tipologie:||01 - Articolo su periodico|