Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir discontinuation in a cohort of patients treated with abacavir-lamivudine-nevirapine.
Abacavir-induced liver toxicity / M.D. Pezzani, C. Resnati, V. Di Cristo, A. Riva, C. Gervasoni. - In: THE BRAZILIAN JOURNAL OF INFECTIOUS DISEASES. - ISSN 1413-8670. - 20:5(2016 Apr 04), pp. 502-504. [10.1016/j.bjid.2016.03.002]
Abacavir-induced liver toxicity
M.D. PezzaniPrimo
;C. ResnatiSecondo
;V. Di Cristo;A. Riva;
2016
Abstract
Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir discontinuation in a cohort of patients treated with abacavir-lamivudine-nevirapine.
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