Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the ‘Stomach cancer Pooling (StoP) Project’, including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09–1.32) for ever, 1.12 (95% CI: 0.99–1.27) for former, and 1.25 (95% CI: 1.11–1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10–1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14–1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.

Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project / D. Praud, M. Rota, C. Pelucchi, P. Bertuccio, T. Rosso, C. Galeone, Z. Zhang, K. Matsuo, H. Ito, J. Hu, K.C. Johnson, G. Yu, D. Palli, M. Ferraroni, J. Muscat, N. Lunet, B. Peleteiro, R. Malekzadeh, W. Ye, H. Song, D. Zaridze, D. Maximovitch, N. Aragonés, G. Castaño Vinyals, J. Vioque, E.M. Navarrete Muñoz, M. Pakseresht, F. Pourfarzi, A. Wolk, N. Orsini, A. Bellavia, N. Håkansson, L. Mu, R. Pastorino, R.C. Kurtz, M.H. Derakhshan, A. Lagiou, P. Lagiou, P. Boffetta, S. Boccia, E. Negri, C. La Vecchia. - In: EUROPEAN JOURNAL OF CANCER PREVENTION. - ISSN 0959-8278. - 27:2(2018 Mar), pp. 124-133. [10.1097/CEJ.0000000000000290]

Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

D. Praud
Primo
;
M. Rota
Secondo
;
C. Pelucchi;P. Bertuccio;T. Rosso;C. Galeone;M. Ferraroni;E. Negri
Penultimo
;
C. La Vecchia
Ultimo
2018-03

Abstract

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the ‘Stomach cancer Pooling (StoP) Project’, including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09–1.32) for ever, 1.12 (95% CI: 0.99–1.27) for former, and 1.25 (95% CI: 1.11–1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10–1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14–1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.
epidemiology; oncology; public health, environmental and occupational health; cancer research
Settore MED/01 - Statistica Medica
24-ago-2016
Article (author)
File in questo prodotto:
File Dimensione Formato  
2016_Praud_EJCP2016.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 716.01 kB
Formato Adobe PDF
716.01 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
123919.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 648.32 kB
Formato Adobe PDF
648.32 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/464190
Citazioni
  • ???jsp.display-item.citation.pmc??? 42
  • Scopus 90
  • ???jsp.display-item.citation.isi??? 78
social impact