The radical polymerization of 1-vinylpyrrolidin-2-one (NVP) in poly(lactic-co-glycolic acid) (PLGA) 50: 50 at 100 degrees C leads to amphiphilic PLGA-g-PVP copolymers. Their composition is determined by FT-IR spectroscopy. Thermogravimetric analyses agree with FT-IR determinations. Saponification of the PLGA-g-PVP polyester portion allows isolating the PVP side chains and measuring their molecular weight, from which the average chain transfer constant (C-T) of the PLGA units is estimated. The MALDI-TOF spectra of PVP reveal the presence at one chain end of residues of either glycolic acid-or lactic acid- or lactic/glycolic acid dimers, trimers and one tetramer, the other terminal being hydrogen. This unequivocally demonstrates that grafting occurred. Accordingly, the orthogonal solvent pair ethyl acetate-methanol, while separating the components of PLGA/PVP intimate mixtures, fails to separate pure PVP or PLGA from the reaction products. All PLGA-g-PVP and PLGA/PLGA-g-PVP blends, but not PLGA/PVP blends, give long-time stable dispersions in water.

One-step synthesis of poly(lactic-co-glycolic acid)-g-poly-1-vinylpyrrolidin-2-one copolymers / E. Ranucci, G. Capuano, A. Manfredi, P. Ferruti. - In: JOURNAL OF POLYMER SCIENCE. PART A, POLYMER CHEMISTRY. - ISSN 0887-624X. - 54:13(2016 Jul), pp. 1919-1928. [10.1002/pola.28049]

One-step synthesis of poly(lactic-co-glycolic acid)-g-poly-1-vinylpyrrolidin-2-one copolymers

E. Ranucci
Primo
;
G. Capuano
Secondo
;
A. Manfredi
Penultimo
;
P. Ferruti
Ultimo
2016

Abstract

The radical polymerization of 1-vinylpyrrolidin-2-one (NVP) in poly(lactic-co-glycolic acid) (PLGA) 50: 50 at 100 degrees C leads to amphiphilic PLGA-g-PVP copolymers. Their composition is determined by FT-IR spectroscopy. Thermogravimetric analyses agree with FT-IR determinations. Saponification of the PLGA-g-PVP polyester portion allows isolating the PVP side chains and measuring their molecular weight, from which the average chain transfer constant (C-T) of the PLGA units is estimated. The MALDI-TOF spectra of PVP reveal the presence at one chain end of residues of either glycolic acid-or lactic acid- or lactic/glycolic acid dimers, trimers and one tetramer, the other terminal being hydrogen. This unequivocally demonstrates that grafting occurred. Accordingly, the orthogonal solvent pair ethyl acetate-methanol, while separating the components of PLGA/PVP intimate mixtures, fails to separate pure PVP or PLGA from the reaction products. All PLGA-g-PVP and PLGA/PLGA-g-PVP blends, but not PLGA/PVP blends, give long-time stable dispersions in water.
amphiphiles; biodegradable; graft copolymers; poly(lactic-co-glycolic acid); PVP
Settore CHIM/04 - Chimica Industriale
lug-2016
feb-2016
Article (author)
File in questo prodotto:
File Dimensione Formato  
RanucciEtAlii_JournalPolymerScience_OneStep_2016.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 631.54 kB
Formato Adobe PDF
631.54 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/464079
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact