Purpose: To prospectively assess whether choline levels and Apparent Diffusion Coefficient (ADC) values within cervical cancers before, during, and after non-surgical therapy are predictive of tumour response. Patients and methods: Patients undergoing MR examination for staging of cervical cancer, candidate for non-surgical therapy, were prospectively enrolled. According to the status at the end of therapies, patients were divided into responders and non-responders. The final outcome after a 5-year follow-up was classified as No Evidence of Disease (NED) or Progression of Disease (PD). Baseline values of mean ADC and Cho/H2O were compared between responders and non-responders, as well as between patients with NED and PD. The percent variation of ADC and Cho/H2O values over time was compared. P valuesÂ <0.05 were considered significant. Results: 16 patients were included. There was no significant difference at baseline between responders (nÂ =Â 12) and non-responders (nÂ =Â 4), nor between NED (nÂ =Â 11) PD patients (nÂ =Â 5), in ADC values and Cho/H2O ratio. There was no significant difference in percent variation of ADC values and of Cho/H2O, comparing responders and non-responders. There was a significant increase in absolute values of ADC from the initial to mid-therapy MRI (pÂ =Â 0.0001), while Cho/H2O was stable (p value: 0.61). In the four non-responders, the ADC increase was not significant (p value: 0.25), while it was significant in the 11 responders (p value: 0.001). Values of spectroscopy were stable in both responders and non-responders. Conclusions: High increases of ADC values from baseline to mid-therapy MR reflect response to therapies. There were no significant variations in choline/water ratios over time.
Evaluation of diffusion-weighted imaging (DWI) and MR spectroscopy (MRS) as early response biomarkers in cervical cancer patients / S. Rizzo, V. Buscarino, D. Origgi, P. Summers, S. Raimondi, R. Lazzari, F. Landoni, M. Bellomi. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 121:11(2016 Nov), pp. 838-846.
|Titolo:||Evaluation of diffusion-weighted imaging (DWI) and MR spectroscopy (MRS) as early response biomarkers in cervical cancer patients|
BUSCARINO, VALENTINA (Secondo)
BELLOMI, MASSIMO (Ultimo)
|Parole Chiave:||Cervical cancer; DWI; MR spectroscopy; Response biomarkers; Radiology, Nuclear Medicine and Imaging|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Data di pubblicazione:||nov-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11547-016-0665-y|
|Appare nelle tipologie:||01 - Articolo su periodico|