We tested the hypothesis that the individual ventilatory adaptation to high altitude (HA, 5050 m) may influence renal water excretion in response to water loading. In 8 healthy humans (33 ± 4 S.D. years) we studied, at sea level (SL) and at HA, resting ventilation (over(V, ̇)E), arterial oxygen saturation (S pO2), urinary output after water loading (WL, 20 mL/kg), and total body water (TBW). Ventilatory response to HA was defined as the difference in resting over(V, ̇)E over S pO2 (Δ over(V, ̇)E / Δ S pO2) from SL to HA. At HA, a significant increase in urinary volume after the first hour from WL (%WLt(0-60)) was observed. Significant correlations were found between Δ over(V, ̇)E / Δ S pO2 versus %WLt(0-60) at HA and versus changes in TBW, from SL to HA. In conclusion, in healthy subjects the ventilatory response to HA influences water balance and correlates with kidney response to WL. A higher ventilatory response at HA, allowing a more efficient water renal handling, is likely to be a protective mechanisms from altitude illness.
Relationship between individual ventilatory response and acute renal water excretion at high altitude / G. Valli, D. Bonardi, F. Campigotto, V. Fasano, A. Gennari, L. Pomodori, A. Cogo, P. Palange. - In: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. - ISSN 1569-9048. - 162:2(2008 Apr 30), pp. 103-108.
Relationship between individual ventilatory response and acute renal water excretion at high altitude
V. Fasano;
2008
Abstract
We tested the hypothesis that the individual ventilatory adaptation to high altitude (HA, 5050 m) may influence renal water excretion in response to water loading. In 8 healthy humans (33 ± 4 S.D. years) we studied, at sea level (SL) and at HA, resting ventilation (over(V, ̇)E), arterial oxygen saturation (S pO2), urinary output after water loading (WL, 20 mL/kg), and total body water (TBW). Ventilatory response to HA was defined as the difference in resting over(V, ̇)E over S pO2 (Δ over(V, ̇)E / Δ S pO2) from SL to HA. At HA, a significant increase in urinary volume after the first hour from WL (%WLt(0-60)) was observed. Significant correlations were found between Δ over(V, ̇)E / Δ S pO2 versus %WLt(0-60) at HA and versus changes in TBW, from SL to HA. In conclusion, in healthy subjects the ventilatory response to HA influences water balance and correlates with kidney response to WL. A higher ventilatory response at HA, allowing a more efficient water renal handling, is likely to be a protective mechanisms from altitude illness.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.