Purpose: To present a single-center experience on pituitary tumor apoplexy and a review of literature focusing on predisposing and precipitating factors. Methods: Clinical presentation of our series of cases. Contemporary published literature is also reviewed. Results: The definition of this syndrome has not been consistent although now the majority of authors agree to definite it as an acute condition caused by hemorrhage or infarction of a pre-existing pituitary adenoma. Different predisposing and precipitating factors have been described in literature; among these antithrombotic and anticoagulant drugs, seem to play relevant roles. The clinical cases observed in our clinic confirm these data and suggest a probable association between elderly patients taking anticoagulant therapy and pituitary apoplexy adenoma. Conclusion: Pituitary tumor apoplexy remains a challenging disease in relation to difficulties in correct diagnosis and thus in appropriate treatment. Antithrombotic/anticoagulant therapy may have an important role as precipitating factor. When a pituitary disorder is known, great care should be taken in the prescription of anticoagulant therapy.

Pituitary apoplexy : considerations on a single center experience and review of the literature / L. Giammattei, G. Mantovani, G. Carrabba, S. Ferrero, A. Di Cristofori, E. Verrua, C. Guastella, L. Pignataro, P. Rampini, M. Minichiello, M. Locatelli. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 39:7(2016 Jul), pp. 739-746. [10.1007/s40618-015-0424-2]

Pituitary apoplexy : considerations on a single center experience and review of the literature

L. Giammattei
Primo
;
G. Mantovani
Secondo
;
G. Carrabba;S. Ferrero;A. Di Cristofori;E. Verrua;L. Pignataro;M. Minichiello
Penultimo
;
M. Locatelli
Ultimo
2016

Abstract

Purpose: To present a single-center experience on pituitary tumor apoplexy and a review of literature focusing on predisposing and precipitating factors. Methods: Clinical presentation of our series of cases. Contemporary published literature is also reviewed. Results: The definition of this syndrome has not been consistent although now the majority of authors agree to definite it as an acute condition caused by hemorrhage or infarction of a pre-existing pituitary adenoma. Different predisposing and precipitating factors have been described in literature; among these antithrombotic and anticoagulant drugs, seem to play relevant roles. The clinical cases observed in our clinic confirm these data and suggest a probable association between elderly patients taking anticoagulant therapy and pituitary apoplexy adenoma. Conclusion: Pituitary tumor apoplexy remains a challenging disease in relation to difficulties in correct diagnosis and thus in appropriate treatment. Antithrombotic/anticoagulant therapy may have an important role as precipitating factor. When a pituitary disorder is known, great care should be taken in the prescription of anticoagulant therapy.
anticoagulant therapy; apoplexy; pituitary; review; endocrinology, diabetes and metabolism; endocrinology
Settore MED/13 - Endocrinologia
lug-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/459944
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