Purpose: To present a single-center experience on pituitary tumor apoplexy and a review of literature focusing on predisposing and precipitating factors. Methods: Clinical presentation of our series of cases. Contemporary published literature is also reviewed. Results: The definition of this syndrome has not been consistent although now the majority of authors agree to definite it as an acute condition caused by hemorrhage or infarction of a pre-existing pituitary adenoma. Different predisposing and precipitating factors have been described in literature; among these antithrombotic and anticoagulant drugs, seem to play relevant roles. The clinical cases observed in our clinic confirm these data and suggest a probable association between elderly patients taking anticoagulant therapy and pituitary apoplexy adenoma. Conclusion: Pituitary tumor apoplexy remains a challenging disease in relation to difficulties in correct diagnosis and thus in appropriate treatment. Antithrombotic/anticoagulant therapy may have an important role as precipitating factor. When a pituitary disorder is known, great care should be taken in the prescription of anticoagulant therapy.
Pituitary apoplexy : considerations on a single center experience and review of the literature / L. Giammattei, G. Mantovani, G. Carrabba, S. Ferrero, A. Di Cristofori, E. Verrua, C. Guastella, L. Pignataro, P. Rampini, M. Minichiello, M. Locatelli. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 39:7(2016 Jul), pp. 739-746.
|Titolo:||Pituitary apoplexy : considerations on a single center experience and review of the literature|
GIAMMATTEI, LORENZO (Primo)
MANTOVANI, GIOVANNA (Secondo)
MINICHIELLO, MARINA (Penultimo)
LOCATELLI, MARCO (Ultimo)
|Parole Chiave:||anticoagulant therapy; apoplexy; pituitary; review; endocrinology, diabetes and metabolism; endocrinology|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||lug-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s40618-015-0424-2|
|Appare nelle tipologie:||01 - Articolo su periodico|