A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well. All compounds were screened against chloroquine resistant W-2 (CQ-R) and chloroquine sensitive, D-10 (CQ-S) strains of Plasmodium falciparum showing IC50 in the submicromolar range and low toxicity against human endothelial cells.
Modified quaternary ammonium salts as potential antimalarial agents / N. Basilico, M. Migotto, D.P. Ilboudo, D. Taramelli, R. Stradi, E. Pini. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 23:15(2015 Aug), pp. 4681-4687.
Modified quaternary ammonium salts as potential antimalarial agents
N. BasilicoPrimo
;D. Taramelli;R. StradiPenultimo
;E. Pini
2015
Abstract
A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well. All compounds were screened against chloroquine resistant W-2 (CQ-R) and chloroquine sensitive, D-10 (CQ-S) strains of Plasmodium falciparum showing IC50 in the submicromolar range and low toxicity against human endothelial cells.
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