Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of human epilepsy, and it is often resistant to conventional antiepileptic drug (AED) therapy. Here we tested whether a single intrahippocampal administration of the synaptic blocker botulinum neurotoxin E (BoNT/E) is effective in reducing spontaneous recurrent seizures (SRS) in a mouse model of MTLE. Unilateral intrahippocampal injection of kainic acid (KA) in mice was used as a model of MTLE. Electroencephalography (EEG) recordings of SRS were performed during the chronic phase of epilepsy, before and after administration of either BoNT/E or vehicle. Frequency of SRS was significantly decreased for at least 5 days following BoNT/E, but not vehicle, infusion. Our findings demonstrate that BoNT/E can effectively reduce seizure incidence in a mouse model of MTLE.
Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy / F. Antonucci, Y. Bozzi, M. Caleo. - In: EPILEPSIA. - ISSN 1528-1167. - 50:4(2009 Apr), pp. 963-966.
|Titolo:||Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy|
ANTONUCCI, FLAVIA (Primo)
|Parole Chiave:||mesial temporal lobe epilepsy; spontaneous recurrent seizures; Kainic acid; SNAP-25; granule cell dispersion|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1528-1167.2008.01983.x|
|Appare nelle tipologie:||01 - Articolo su periodico|