Th17 cells are a heterogeneous population of pro-inflammatory T cells that have been shown to mediate immune responses against intestinal bacteria. Th17 cells are highly plastic and can transdifferentiate to Th1/17 cells or unconventional Th1 cells, which are highly pathogenic in animal models of immune-mediated diseases such as inflammatory bowel diseases. A recent European Journal of Immunology article by Liu et al. (Eur. J. Immunol. 2015. 45:1010–1018) showed, surprisingly, that Th1 cells have a similar plasticity, and could transdifferentiate to Th17 cells. Thus, IFN-γ-producing Th1 effector cells specific for an intestinal microbial antigen were shown to acquire IL-17-producing capacities in the gut in a mouse model of colitis, and in response to TGF-β and IL-6 in vitro. TGF-β induced Runx1, and together with IL-6 was shown to render the ROR-γt and IL-17 promoters in Th1 cells accessible for Runx1 binding. In this commentary, we discuss how this unexpected plasticity of Th1 cells challenges our view on the generation of Th1/17 cells with the capacity to co-produce IL-17 and IFN-γ, and consider possible implications of this Th1-to-Th17-cell conversion for therapies of inflammatory bowel diseases and protective immune responses against intracellular pathogens.

Reverse plasticity : TGF-β and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut / J. Geginat, M. Paroni, I. Kastirr, P. Larghi, M. Pagani, S. Abrignani. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 46:10(2016 Oct), pp. 2306-2310. [10.1002/eji.201646618]

Reverse plasticity : TGF-β and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut

J. Geginat;M. Paroni;M. Pagani
Penultimo
;
S. Abrignani
Ultimo
2016

Abstract

Th17 cells are a heterogeneous population of pro-inflammatory T cells that have been shown to mediate immune responses against intestinal bacteria. Th17 cells are highly plastic and can transdifferentiate to Th1/17 cells or unconventional Th1 cells, which are highly pathogenic in animal models of immune-mediated diseases such as inflammatory bowel diseases. A recent European Journal of Immunology article by Liu et al. (Eur. J. Immunol. 2015. 45:1010–1018) showed, surprisingly, that Th1 cells have a similar plasticity, and could transdifferentiate to Th17 cells. Thus, IFN-γ-producing Th1 effector cells specific for an intestinal microbial antigen were shown to acquire IL-17-producing capacities in the gut in a mouse model of colitis, and in response to TGF-β and IL-6 in vitro. TGF-β induced Runx1, and together with IL-6 was shown to render the ROR-γt and IL-17 promoters in Th1 cells accessible for Runx1 binding. In this commentary, we discuss how this unexpected plasticity of Th1 cells challenges our view on the generation of Th1/17 cells with the capacity to co-produce IL-17 and IFN-γ, and consider possible implications of this Th1-to-Th17-cell conversion for therapies of inflammatory bowel diseases and protective immune responses against intracellular pathogens.
No
English
plasticity; runx1; TGF-β; Th1; Th17; immunology and allergy; immunology
Settore BIO/11 - Biologia Molecolare
Articolo
Esperti anonimi
Pubblicazione scientifica
ott-2016
Wiley
46
10
2306
2310
5
Pubblicato
Periodico con rilevanza internazionale
scopus
pubmed
crossref
Aderisco
info:eu-repo/semantics/article
Reverse plasticity : TGF-β and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut / J. Geginat, M. Paroni, I. Kastirr, P. Larghi, M. Pagani, S. Abrignani. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 46:10(2016 Oct), pp. 2306-2310. [10.1002/eji.201646618]
reserved
Prodotti della ricerca::01 - Articolo su periodico
6
262
Article (author)
no
J. Geginat, M. Paroni, I. Kastirr, P. Larghi, M. Pagani, S. Abrignani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/456338
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