Background: Plasma lipoprotein(a) [Lp(a)] levels are mainly genetically determined. The C93T polymorphism is a naturally occurring variant of the LPA gene that may influence Lp(a) concentration. The role of Lp(a) in the pathogenesis of peripheral arterial disease (PAD) has not been firmly established. Methods: A total of 299 patients with PAD and 312 PAD-free control subjects were investigated. Genotyping of the LPA C93T polymorphism was performed by means of PCR-RFLPs. Plasma Lp(a) levels were determined by ELISA. Results: Subjects carrying at least one LPA 93T allele had lower Lp(a) levels. The prevalence rate of the 93T allele was significantly higher in control subjects (19.5%) than in PAD patients (13.0%, P = 0.012). In multivariate logistic regression analysis with covariates including traditional risk factors, the 93T allele was independently associated with a reduced risk of PAD (OR = 0.75, 95% CI = 0.51-0.95, P = 0.031). Conclusion: The 93T allele of the LPA gene is associated with a reduced risk of PAD and low Lp(a) levels.

The LPA gene C93T polymorphism influences plasma lipoprotein(a) levels and is independently associated with susceptibility to peripheral arterial disease / M. Catalano, A. Cortelazzo, Y. Yilmaz, E. Perilli, G. Carzaniga, E. Emanuele. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - 387:1-2(2008), pp. 109-112. [10.1016/j.cca.2007.09.014]

The LPA gene C93T polymorphism influences plasma lipoprotein(a) levels and is independently associated with susceptibility to peripheral arterial disease

M. Catalano
Primo
;
A. Cortelazzo
Secondo
;
G. Carzaniga
Penultimo
;
2008

Abstract

Background: Plasma lipoprotein(a) [Lp(a)] levels are mainly genetically determined. The C93T polymorphism is a naturally occurring variant of the LPA gene that may influence Lp(a) concentration. The role of Lp(a) in the pathogenesis of peripheral arterial disease (PAD) has not been firmly established. Methods: A total of 299 patients with PAD and 312 PAD-free control subjects were investigated. Genotyping of the LPA C93T polymorphism was performed by means of PCR-RFLPs. Plasma Lp(a) levels were determined by ELISA. Results: Subjects carrying at least one LPA 93T allele had lower Lp(a) levels. The prevalence rate of the 93T allele was significantly higher in control subjects (19.5%) than in PAD patients (13.0%, P = 0.012). In multivariate logistic regression analysis with covariates including traditional risk factors, the 93T allele was independently associated with a reduced risk of PAD (OR = 0.75, 95% CI = 0.51-0.95, P = 0.031). Conclusion: The 93T allele of the LPA gene is associated with a reduced risk of PAD and low Lp(a) levels.
Atherosclerosis; Lipoprotein(a); Peripheral arterial disease; Polymorphism
Settore MED/09 - Medicina Interna
2008
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/45627
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