Background: Plasma lipoprotein(a) [Lp(a)] levels are mainly genetically determined. The C93T polymorphism is a naturally occurring variant of the LPA gene that may influence Lp(a) concentration. The role of Lp(a) in the pathogenesis of peripheral arterial disease (PAD) has not been firmly established. Methods: A total of 299 patients with PAD and 312 PAD-free control subjects were investigated. Genotyping of the LPA C93T polymorphism was performed by means of PCR-RFLPs. Plasma Lp(a) levels were determined by ELISA. Results: Subjects carrying at least one LPA 93T allele had lower Lp(a) levels. The prevalence rate of the 93T allele was significantly higher in control subjects (19.5%) than in PAD patients (13.0%, P = 0.012). In multivariate logistic regression analysis with covariates including traditional risk factors, the 93T allele was independently associated with a reduced risk of PAD (OR = 0.75, 95% CI = 0.51-0.95, P = 0.031). Conclusion: The 93T allele of the LPA gene is associated with a reduced risk of PAD and low Lp(a) levels.
|Titolo:||The LPA gene C93T polymorphism influences plasma lipoprotein(a) levels and is independently associated with susceptibility to peripheral arterial disease|
|Autori interni:||CATALANO, MARIA (Primo)|
CORTELAZZO, ADRIANO GIOVANNI (Secondo)
CARZANIGA, GIANNI SERGIO (Penultimo)
|Parole Chiave:||Atherosclerosis; Lipoprotein(a); Peripheral arterial disease; Polymorphism|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2008|
|Digital Object Identifier (DOI):||10.1016/j.cca.2007.09.014|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
- PubMed Central loading...