The last decade has witnessed a huge growth in the use of flow chemistry as well established procedure for performing chemical transformations; indeed, under continuous flow conditions, more sustainable, safer and easier scalable processes could be developed with respect to conventional batch procedures. Organocatalysis has recently become an effective methodology for performing stereoselective reactions in continuo: metal-free catalytic processes could ensure high levels of enantioselectivity avoiding the contamination of final products with potentially toxic metal species. Since many academic research groups are focusing their efforts in this field, in the near future stereoselective catalytic flow processes could found a practical application in the manufacturing of Active Pharmaceutical Ingredients and chiral intermediates. In the present review most recent examples of continuous flow processes employing organic molecules as catalysts will be discussed. A particular attention will be devoted to stereoselective reactions promoted by chiral organocatalysts under continuous flow conditions. Moreover, the great potential in combining flow stereoselective processes with solidsupported catalysis in catalytic reactors as well as with photoredox catalysis will be highlighted.

Organocatalysis Chemistry in Flow / A. Puglisi, M. Benaglia, R. Porta, F. Coccia. - In: CURRENT ORGANOCATALYSIS. - ISSN 2213-3380. - 2:2(2015), pp. 79-101. [10.2174/2213337202666150513002701]

Organocatalysis Chemistry in Flow

A. Puglisi;M. Benaglia;R. Porta;F. Coccia
2015

Abstract

The last decade has witnessed a huge growth in the use of flow chemistry as well established procedure for performing chemical transformations; indeed, under continuous flow conditions, more sustainable, safer and easier scalable processes could be developed with respect to conventional batch procedures. Organocatalysis has recently become an effective methodology for performing stereoselective reactions in continuo: metal-free catalytic processes could ensure high levels of enantioselectivity avoiding the contamination of final products with potentially toxic metal species. Since many academic research groups are focusing their efforts in this field, in the near future stereoselective catalytic flow processes could found a practical application in the manufacturing of Active Pharmaceutical Ingredients and chiral intermediates. In the present review most recent examples of continuous flow processes employing organic molecules as catalysts will be discussed. A particular attention will be devoted to stereoselective reactions promoted by chiral organocatalysts under continuous flow conditions. Moreover, the great potential in combining flow stereoselective processes with solidsupported catalysis in catalytic reactors as well as with photoredox catalysis will be highlighted.
Catalytic reactors, flow chemistry, microreactors, organocatalysis, photoredox catalysis, stereoselective synthesis, supported chiral organocatalysts
Settore CHIM/06 - Chimica Organica
CURRENT ORGANOCATALYSIS
Article (author)
File in questo prodotto:
File Dimensione Formato  
Current Organocatalysis_2015_79.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 1.31 MB
Formato Adobe PDF
1.31 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/455128
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 26
social impact