BACKGROUND AND AIMS: The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. METHODS AND RESULTS: Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95%CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys. CONCLUSIONS: Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences.
Association of early protein intake and pre-peritoneal fat at five years of age : Follow-up of a randomized clinical trial / D. Gruszfeld, M. Weber, K. Gradowska, P. Socha, V. Grote, A. Xhonneux, E. Dain, E. Verduci, E. Riva, R. Closa-Monasterolo, J. Escribano, B. Koletzko. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 1590-3729. - 26:9(2016 Sep), pp. 824-832.
|Titolo:||Association of early protein intake and pre-peritoneal fat at five years of age : Follow-up of a randomized clinical trial|
|Parole Chiave:||child; dietary proteins; Infant formula; Intra-abdominal fat; protein; subcutaneous fat|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Progetto:||Long-term effects of early nutrition on later health|
|Data di pubblicazione:||set-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.numecd.2016.04.005|
|Appare nelle tipologie:||01 - Articolo su periodico|