Association of early protein intake and pre-peritoneal fat at five years of age : Follow-up of a randomized clinical trial

Gruszfeld, D.; Weber, M.; Gradowska, K.; Socha, P.; Grote, V.; Xhonneux, A.; Dain, E.; Verduci, E.; Riva, E.; Closa Monasterolo, R.; Escribano, J.; Koletzko, B.

doi:10.1016/j.numecd.2016.04.005

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BACKGROUND AND AIMS: The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. METHODS AND RESULTS: Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95%CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys. CONCLUSIONS: Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences.

Association of early protein intake and pre-peritoneal fat at five years of age : Follow-up of a randomized clinical trial / D. Gruszfeld, M. Weber, K. Gradowska, P. Socha, V. Grote, A. Xhonneux, E. Dain, E. Verduci, E. Riva, R. Closa-Monasterolo, J. Escribano, B. Koletzko. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 1590-3729. - 26:9(2016 Sep), pp. 824-832.

Titolo:	Association of early protein intake and pre-peritoneal fat at five years of age : Follow-up of a randomized clinical trial
Autori:	D. Gruszfeld M. Weber K. Gradowska P. Socha V. Grote A. Xhonneux E. Dain VERDUCI, ELVIRA RIVA, ENRICA LICIA R. Closa Monasterolo J. Escribano B. Koletzko mostra contributor esterni nascondi contributor esterni
Parole Chiave:	child; dietary proteins; Infant formula; Intra-abdominal fat; protein; subcutaneous fat
Settore Scientifico Disciplinare:	Settore MED/38 - Pediatria Generale e Specialistica
Progetto:	Long-term effects of early nutrition on later health
Data di pubblicazione:	set-2016
Rivista:	NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.numecd.2016.04.005
Appare nelle tipologie:	01 - Articolo su periodico

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