It has been suggested that polycythemia vera (PV) could be preceded by an "early" phase of the disease (e-PV), in which the increase in the red cell parameters is lower than required for a PV diagnosis. In this study, we compared the clinicopathologic and molecular features of 17 patients with e-PV with those of 14 patients with essential thrombocythemia (ET) and 19 with PV. The results for e-PV were more similar to those for PV than for ET. In fact, patients with e-PV were characterized by an increase in the red cell parameters, splenomegaly (P < .05), and hepatomegaly (P = .038), together with hypercellular bone marrow due to increased erythropoiesis and granulopoiesis, associated with megakaryocytic hyperplasia, with pleomorphic aggregates (P < .001). The frequency of the JAK2V617F mutation was similar in e-PV (16 cases tested [100%]) and PV (18/19 [95%]) but was significantly lower (7/13 [54%]) in ET (P = .0007). We propose a diagnostic algorithm helpful to distinguish ET from the early prepolycythemic phase of PV.
|Titolo:||The significance of bone marrow biopsy and JAK2V617F mutation in the differential diagnosis between the "early" prepolycythemic phase of polycythemia vera and essential thrombocythemia|
|Parole Chiave:||Bone marrow biopsy; Differential diagnosis; Early prepolycythemic polycythemia vera; Essential thrombocythemia; JAK2V617F mutation; Polycythemia vera|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
Settore MED/08 - Anatomia Patologica
|Data di pubblicazione:||set-2008|
|Digital Object Identifier (DOI):||10.1309/6BQ5K8LHVYAKUAF4|
|Appare nelle tipologie:||01 - Articolo su periodico|