Ovarian endometriomas are found in a consistent proportion of patients with endometriosis and are associated with a more severe form of the disease. The endometriotic tissue lining the inside of the endometrioma has been extensively studied over the years mostly for the need to compare the molecular and cellular characteristics of eutopic and ectopic endometria. Several aspects of hormonal regulation, response to local inflammation, carcinogenesis, and modifications of the local environment have been investigated in order to characterize also the processes associated with peritoneal endometriosis. In this review, we have summarized the current knowledge of pathophysiology of endometrioma, with a particular focus on the cellular components lining the internal surface of the cyst in order to provide a comprehensive overview of the hormonal, genetic, epigenetic, and gene expression profiles of this essential part of the cyst.

The endometriotic tissue lining the internal surface of endometrioma : hormonal, genetic, epigenetic status, and gene expression profile / A.M. Sanchez, P. Viganò, E. Somigliana, R. Cioffi, P. Panina Bordignon, M. Candiani. - In: REPRODUCTIVE SCIENCES. - ISSN 1933-7191. - 22:4(2015), pp. 391-401. [10.1177/1933719114529374]

The endometriotic tissue lining the internal surface of endometrioma : hormonal, genetic, epigenetic status, and gene expression profile

P. Viganò;E. Somigliana;M. Candiani
2015

Abstract

Ovarian endometriomas are found in a consistent proportion of patients with endometriosis and are associated with a more severe form of the disease. The endometriotic tissue lining the inside of the endometrioma has been extensively studied over the years mostly for the need to compare the molecular and cellular characteristics of eutopic and ectopic endometria. Several aspects of hormonal regulation, response to local inflammation, carcinogenesis, and modifications of the local environment have been investigated in order to characterize also the processes associated with peritoneal endometriosis. In this review, we have summarized the current knowledge of pathophysiology of endometrioma, with a particular focus on the cellular components lining the internal surface of the cyst in order to provide a comprehensive overview of the hormonal, genetic, epigenetic, and gene expression profiles of this essential part of the cyst.
endometrioma; gene expression; oxidative status; Animals; Embryo Implantation; Endometriosis; Endometrium; Female; Gene Expression Regulation; Genetic Markers; Genetic Predisposition to Disease; Hormones; Humans; Infertility, Female; Phenotype; Risk Factors; Epigenesis, Genetic; Gene Expression Profiling; Obstetrics and Gynecology
Settore MED/40 - Ginecologia e Ostetricia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/453828
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