Research findings are inconsistent about improvement of specific cardio-metabolic variables after lifestyle intervention in obese children. The aim of this trial was to evaluate the effect of a 1-year intervention, based on normocaloric diet and physical activity, on body mass index (BMI), blood lipid profile, glucose metabolism and metabolic syndrome. Eighty-five obese children aged ≥6 years were analyzed. The BMI z-score was calculated. Fasting blood samples were analyzed for lipids, insulin and glucose. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated and insulin resistance was defined as HOMA-IR >3.16. HOMA-β%, quantitative insulin sensitivity check index and triglyceride glucose index were calculated. The metabolic syndrome was defined in accordance with the International Diabetes Federation criteria. At the end of intervention children showed a reduction (mean (95% CI)) in BMI z-score (−0.58 (−0.66; −0.50)), triglycerides (−0.35 (−0.45; −0.25) mmol/L) and triglyceride glucose index (−0.29 (−0.37; −0.21)), and an increase in HDL cholesterol (0.06 (0.01; 0.11) mmol/L). Prevalence of insulin resistance declined from 51.8% to 36.5% and prevalence of metabolic syndrome from 17.1% to 4.9%. Nutritional-behavioral interventions can improve the blood lipid profile and insulin sensitivity in obese children, and possibly provide benefits in terms of metabolic syndrome.
Change in metabolic profile after 1-year nutritional-behavioral intervention in obese children / E. Verduci, C. Lassandro, R. Giacchero, V.L. Miniello, G. Banderali, G. Radaelli. - In: NUTRIENTS. - ISSN 2072-6643. - 7:12(2015 Dec 03), pp. 10089-10099.
|Titolo:||Change in metabolic profile after 1-year nutritional-behavioral intervention in obese children|
VERDUCI, ELVIRA (Corresponding)
LASSANDRO, CARLOTTA (Secondo)
|Parole Chiave:||Childhood obesity; Glucose metabolism; Lipid profile; Metabolic syndrome; Nutritional-behavioral intervention; Adolescent; Blood Glucose; Blood Pressure; Body Mass Index; Child; Cholesterol, HDL; Energy Intake; Female; Humans; Insulin; Insulin Resistance; Life Style; Longitudinal Studies; Male; Metabolic Syndrome X; Motor Activity; Pediatric Obesity; Prevalence; Triglycerides; Child Nutritional Physiological Phenomena; Health Behavior; Metabolome; Food Science|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||3-dic-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nu7125520|
|Appare nelle tipologie:||01 - Articolo su periodico|