4 children with isolated growth hormone deficiency (IGHD) and 4 with constitutional growth delay (CGD) were treated with clonidine, 0·1 mg/m2 daily, for 60 days. In 2 children with IGHD and all 4 with CGD, basal growth hormone (GH) and somatomedin-C levels were increased, pituitary GH response to challenges with a synthetic pancreatic GH releasing factor and clonidine was enhanced, and linear growth was stimulated.
Clonidine accelerates growth in children with impaired growth-hormone secretion / C. Pintor, R. Corda, R. Puggioni, S. Cella, V. Locatelli, S. Loche, E. Müller. - In: THE LANCET. - ISSN 0140-6736. - 325:8444(1985), pp. 1482-1485. [10.1016/S0140-6736(85)92256-1]
Clonidine accelerates growth in children with impaired growth-hormone secretion
S. Cella;
1985
Abstract
4 children with isolated growth hormone deficiency (IGHD) and 4 with constitutional growth delay (CGD) were treated with clonidine, 0·1 mg/m2 daily, for 60 days. In 2 children with IGHD and all 4 with CGD, basal growth hormone (GH) and somatomedin-C levels were increased, pituitary GH response to challenges with a synthetic pancreatic GH releasing factor and clonidine was enhanced, and linear growth was stimulated.
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