A review. Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release through their cleavage of components of the exocytosis machinery. These toxins are used to treat human diseases that are characterized by hyperfunction of cholinergic terminals. Recently, evidence has accumulated that gangliosides and synaptic vesicle proteins cooperate to mediate toxin binding to the presynaptic terminal. The differential distribution of synaptic vesicle protein receptors, gangliosides and toxin substrates in distinct neuronal populations opens up the possibility of using different serotypes of botulinum toxins for the treatment of central nervous system diseases caused by altered activity of selected neuronal populations.

Entering neurons : botulinum toxins and synaptic vesicle recycling / C. Verderio, O. Rossetto, C. Grumelli, C. Frassoni, C. Montecucco, M. Matteoli. - In: EMBO REPORTS. - ISSN 1469-221X. - 7:10(2006 Oct), pp. 995-999. [10.1038/sj.embor.7400796]

Entering neurons : botulinum toxins and synaptic vesicle recycling

C. Grumelli;M. Matteoli
Ultimo
2006

Abstract

A review. Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release through their cleavage of components of the exocytosis machinery. These toxins are used to treat human diseases that are characterized by hyperfunction of cholinergic terminals. Recently, evidence has accumulated that gangliosides and synaptic vesicle proteins cooperate to mediate toxin binding to the presynaptic terminal. The differential distribution of synaptic vesicle protein receptors, gangliosides and toxin substrates in distinct neuronal populations opens up the possibility of using different serotypes of botulinum toxins for the treatment of central nervous system diseases caused by altered activity of selected neuronal populations.
Biological transport ; Human ; Neuron (botulinum toxin uptake by neurons and synaptic vesicle recycling) ; Synapse (synaptic vesicle ; botulinum toxin uptake by neurons and synaptic vesicle recycling)
Settore BIO/14 - Farmacologia
ott-2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/45192
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