Background. Oxidative stress has been related to several pathologies, like coronary artery disease (CAD). We recently described a comprehensive index of oxidative status (OXYSCORE),reflecting both injuries and antioxidant defences in coronary patients. Objective: This study was performed to test OXY-SCORE. Methods. We enrolled 93 healthy subjects (58% males; age 24-72) and 197 CAD patients, 118 with stable angina (SA,77% males; age 40-81) and 79 with acute coronary syndrome (ACS, 70% males; age 35-80) . Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced forms (GSSG/GSH) and urine isoprostane (iPF2α-III) levels were measured as markers of oxidative damage, and computed in the damage score (DS). GSH, α-and γ-tocopherol (TH), and individual antioxidant capacity (IAC), measured as indexes of antioxidant defence, were computed in the protection score (PS). OXY-SCORE was computed by subtracting PS from DS. Data were analysed by ANCOVA and ROC analysis. Results. In healthy subjects, MDA was associated with age and GSH, GSSG/GSH ratio and α-TH correlated with gender. OXY-SCORE (mean±SEM 0.31±0.10), was positively associated with both age (p=0.02) and male gender (p=0.03). OXY-SCORE was significantly higher in CAD subjects even after adjusting for age and gender (p<0.0001) and was also able to discriminate between ACS and AS (mean±SEM 1.4±0.11 and 0.92±0.08 respectively, p=0.001) with an area under the ROC curve of 0.66. Conclusions. OXY-SCORE is confirmed to be a comprehensive index of oxidative stress related to age, gender and CAD status. This marker also reflects the different clinical presentation of CAD.
Oxidative stress : a global evaluation in patients with acute coronary syndrome and stable angina / V. Cavalca, I. Squellerio, G. Cighetti, L. Zingaro, L. Boccotti, E. Tremoli, F. Veglia. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - 45:Suppl. 1(2007), pp. S226-S227. ((Intervento presentato al 17. convegno Euromedlab : IFCC – FESCC European congress of clinical chemistry and laboratory medicine, 3-7 June tenutosi a Amsterdam nel 2007.
|Titolo:||Oxidative stress : a global evaluation in patients with acute coronary syndrome and stable angina|
CAVALCA, VIVIANA MARIA (Primo)
SQUELLERIO, ISABELLA (Secondo)
TREMOLI, ELENA (Penultimo)
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore BIO/14 - Farmacologia
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
|Data di pubblicazione:||2007|
|Enti collegati al convegno:||IFCC International Federation of Clinical Chemistry and Laboratory Medicine|
FESCC Forum of the European Societies of Clinical Chemistry
NVKC Netherlands Society for Clinical Chemistry and Laboratory Medicine
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1515/CCLM.2007.220|
|Appare nelle tipologie:||01 - Articolo su periodico|