A controlled clinical trial was performed to investigate the safety and efficacy of the hyaluronate-based gel polymer Hyaloglide® after microsurgical reconstruction of peripheral nerves of the hand. Thirty patients were randomized to receive either no postsurgical treatment (n = 16) or Hyaloglide® (n = 14) and were clinically evaluated at various intervals for 1 year. The application of Hyaloglide® posed no safety concerns. Efficacy was assessed by the recovery of sensitivity, measurement of pain, and progression of Tinel's sign. The Hyaloglide®-treated group showed better improvement in recovery from pain, approaching statistical significance during the first 3 months postsurgery. Likewise, recovery of sensitivity was also higher in the Hyaloglide®-treated group throughout the entire follow-up period, and the distance of Tinel's sign was longer in the Hyaloglide®-treated group (P < 0.05 at day 30). The application of Hyaloglide® may improve recovery of sensitivity and decrease pain following microsurgical repair of the peripheral nerves of the hand.
|Titolo:||Clinical evaluation of a hyaluronan-based gel following microsurgical reconstruction of peripheral nerves of the hand|
|Autori interni:||PAJARDI, GIORGIO EUGENIO (Penultimo)|
|Settore Scientifico Disciplinare:||Settore MED/19 - Chirurgia Plastica|
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||10.1002/micr.20299|
|Appare nelle tipologie:||01 - Articolo su periodico|